Historical and Social Aspects of Vaccination and the Anti-Vaccination Movement Worldwide: Influences on Serbia
Abstract
Infectious diseases have significantly shaped the course of human history. The earliest recorded pandemic was described during the Peloponnesian War in 430 BC. Since then, numerous smallpox, cholera, and influenza epidemics have been recorded, including the 20th and 21st centuries. This year marks the 228th anniversary of the use of the Jenner smallpox vaccine. For nearly two centuries, vaccines have protected people from infectious diseases and, alongside improved hygiene measures, contributed to a higher quality of life. Despite the well-documented benefits of immunization, vaccine-preventable diseases continue to pose a global threat.
In Serbia, compulsory immunization was introduced as early as 1839, establishing a long-standing tradition of vaccination and domestic vaccine production. In more recent history, Serbia was among the first countries to implement vaccines against whooping cough, mumps, and measles, as well as hepatitis B for at-risk populations.
The anti-vaccine movement employs various strategies to persuade the public that vaccines are unsafe, casting doubt on their quality and on the intentions of those advocating for their use. Globally, anti-vaccine activism fosters vaccine hesitancy or outright refusal, thereby undermining efforts to halt and eradicate infectious diseases. This resistance complicates epidemiological conditions and results in avoidable illnesses and, in some cases, fatalities from diseases that are preventable through safe and effective vaccination. Effective communication is essential to the success of public health interventions, and citizens’ trust in science and the healthcare system must be restored and strengthened.
References
Bean, S. J. (2011). Emerging and continuing trends in vaccine opposition website content. Vaccine, 29(10), 1874–1880. https://doi.org/10.1016/j.vaccine.2011.01.003
BPPJ. (2018, October 25). The Anti-Vaccination Movement Breaks Out in Italy and Beyond. Retrieved August 14, 2024, from: https://bppj.studentorg.berkeley.edu/2018/10/25/the-anti-vaccination-movement-breaks-out-in-italy-and-beyond/
Centers for Disease Control and Prevention. (2002). Vaccination coverage among children aged 19–35 months—United States, 2001. Morbidity and Mortality Weekly Report, 51(37), 829–832.
Centralni higijenski zavod u Beogradu. (1931). Izveštaj o radu Centralnog higijenskog zavoda u Beogradu za 1930. god. Socijalno-medicinski pregled, 2 (5), 146–158.
Cha, A. E. (2015, September 17). The origins of Donald Trump’s autism/vaccine theory and how it was completely debunked eons ago. The Washington Post. https://www.washingtonpost.com/news/to-your-health/wp/2015/09/17/the-origins-of-donaldtrumps-autismvaccine-theory-and-how-it-was-completely-debunked-eons-ago/
Chadwick, C., Friede, M., Moen, A., Nannei, C., & Sparrow, E. (2022). Technology transfer programme for influenza vaccines: Lessons from the past to inform the future. Vaccine, 40(33), 4673–4675. https://doi.org/10.1016/j.vaccine.2022.06.057
College of Physicians of Philadelphia. (2022, April 20). Misconception about Vaccines: History of Anti-Vaccination Movements. https://www.historyofvaccines.org/content/articles/history-anti-vaccination-movements
Deer, B. (2011). How the case against the MMR vaccine was fixed. BMJ, 342, c5347. https://doi.org/10.1136/bmj.c5347
Dovijanić, P. (1972). Socijalno-medicinski aspekti suzbijanja epidemije velikih boginja u Beogradu, mart–maj 1972. godine. U: S. Krajinović, Ž. Perišić, B. Antić, R. Jocić i A. Prelić (ur.), Velike boginje u Jugoslaviji 1972: Zbornik radova sa simpozijuma o suzbijanju velikih boginja na području Beograda, Beograd, 14–16. novembar 1972. (str. 13–25). Beograd: Glas.
Drancourt, M. (2012). Finally, plague is plague. Clinical Microbiology and Infection, 18(2), 105–106. https://doi.org/10.1111/j.1469-0691.2011.03745.x
Durbach, N. (2005). Bodily Matters: The Anti-Vaccination Movement in England, 1853–1907. Durham, NC: Duke University Press. https://doi.org/10.1215/9780822386506
Gostin, L. O. (2005). Jacobson v Massachusetts at 100 years: Police powers and civil liberties in tension. American Journal of Public Health, 95(4), 576–581. https://doi.org/10.2105/AJPH.2004.055152
Great Britain, Local Government Board. (1893). Further Report and Papers on Epidemic Influenza, 1889-92: With an Introduction by the Medical Officer of the Local Government Board. London: Eyre.
de Haan, E., & ten Kate, A. (2023). Pharma’s Pandemic Profits: Pharma Profits from COVID-19 Vaccines. Amsterdam: SOMO.
Hackett, A. J. (2008). Risk, its perception and the media: The MMR controversy. Community Practitioner, 81(7), 22–25.
Hallander, H. O., Advani, A., Donnelly, D., Gustafsson, L., & Carlsson, R. M. (2005). Shifts of Bordetella pertussis variants in Sweden from 1970 to 2003, during three periods marked by different vaccination programs. Journal of Clinical Microbiology, 43(6), 2856–2865. https://doi.org/10.1128/JCM.43.6.2856-2865.2005
Ilić, I., & Ilić, M. (2022). Historical review: Towards the 50th anniversary of the last major smallpox outbreak (Yugoslavia, 1972). Travel Medicine and Infectious Disease, 48, 102327. https://doi.org/10.1016/j.tmaid.2022.102327
Jackson, C. L. (1969). State laws on compulsory immunization in the United States. Public Health Reports, 84(9), 787–795.
Jakovljević, D., Vukmanović, Č. i Dovijanić, P. (1973). Organizacija kontrole karantina u Jugoslaviji na osnovu poslednje epidemije velikih boginja. U: Lj. Stojković, B. Birtašević, S. Borjanović, S. Litvinjenko, Ž. Perišić i V. Šuvaković (ur.), Epidemija velikih boginja u Beogradu 1972: Zbornik radova sa jugoslovenskog simpozijuma o velikim boginjama, Primošten, 21–24. novembar 1972. (str. 253–259). Ljubljana: ČGP Delo.
Janković, S. (2014). Anti-vaccination movements and science-based medicine. Biomedicinska istraživanja, 5 (1), 59–65. https://doi.org/10.7251/BII1401059J
Kršljanin, N. (2021). Legal measures on vaccination against smallpox in the Principality of Serbia in the 1830s–1840s. Anali Pravnog fakulteta u Beogradu, 69 (4), 877–925. https://doi.org/10.51204/Anali_PFBU_21408A
Laurens, M. B. (2019). RTS,S/AS01 vaccine (Mosquirix™): An overview. Human Vaccines & Immunotherapeutics, 16(3), 480–489. https://doi.org/10.1080/21645515.2019.1669415
Lazović, I., & Sujić, R. (2007). Women doctors in the Serbian sanitary service during the Balkan Wars. Acta Medico-Historica Adriatica, 5(1), 71–82.
Mariner, W. K., Annas, G. J., & Glantz, L. H. (2005). Jacobson v. Massachusetts: It’s not your great-great-grandfather’s public health law. American Journal of Public Health, 95(4), 581–590. https://doi.org/10.2105/AJPH.2004.055160
Martini, M., Bifulco, M., & Orsini, D. (2022). Smallpox vaccination and vaccine hesitancy in the Kingdom of the Two Sicilies (1801) and the great modernity of Ferdinand IV of Bourbon: A glimpse of the past in the era of the SARS-CoV-2 (COVID-19) pandemic. Public Health, 213, 47–53. https://doi.org/10.1016/j.puhe.2022.09.012
Mocić, M., Ristić, J., Pavlović, J., Milisavljević, A. i Jorgačević, D. (1973). Encephalitis and encephalomyelitis postvaccinalis: iskustva Bolnice za infektivne bolesti Medicinskog fakulteta u Beogradu. U: Lj. Stojković, B. Birtašević, S. Borjanović, S. Litvinjenko, Ž. Perišić i V. Šuvaković (ur.), Epidemija velikih boginja u Beogradu 1972: Zbornik radova sa jugoslovenskog simpozijuma o velikim boginjama, Primošten, 21–24. novembar 1972. (str. 344–351). Ljubljana: ČGP Delo.
Mravunac, B., Košutić, Z., Borčić, D., Breitenfeld, V. i Puntarić, V. (1973). Komplikacije vakcinacije protiv velikih boginja na širem području Zagreba. U: Lj. Stojković, B. Birtašević, S. Borjanović, S. Litvinjenko, Ž. Perišić i V. Šuvaković (ur.), Epidemija velikih boginja u Beogradu 1972: Zbornik radova sa jugoslovenskog simpozijuma o velikim boginjama, Primošten, 21–24. novembar 1972. (str. 333–338). Ljubljana: ČGP Delo.
Ninković, N., & Vasin, G. (2019). The first encounter of Serbs with smallpox vaccination. У: С. Лазаревић Радак (ур.), Између здравља и болести: поглед са Балкана (стр. 133–144). Београд: Удружење фолклориста Србије – Универзитетска библиотека „Светозар Марковић”.
Ortiz-Sánchez, E., Velando-Soriano, A., Pradas-Hernández, L., Vargas-Román, K., Gómez-Urquiza, J. L., Cañadas-De la Fuente, G. A., & Albendín-García, L. (2020). Analysis of the anti-vaccine movement in social networks: A systematic review. International Journal of Environmental Research and Public Health, 17(15), 5394. https://doi.org/10.3390/ijerph17155394
Pavli, A., & Maltezou, H. C. (2022). Travel vaccines throughout history. Travel Medicine and Infectious Disease, 46, 102278. https://doi.org/10.1016/j.tmaid.2022.102278
Radovanović, Z. (2017). Istina o vakcinama. Priručnik za savesne roditelje (2. dopunjeno i prošireno izdanje). Smederevo: Heliks.
Ranitović, S. (1973). Iskustva u masovnoj vakcinaciji – postvakcinalne reakcije i komplikacije. U: Lj. Stojković, B. Birtašević, S. Borjanović, S. Litvinjenko, Ž. Perišić i V. Šuvaković (ur.), Epidemija velikih boginja u Beogradu 1972: Zbornik radova sa jugoslovenskog simpozijuma o velikim boginjama, Primošten, 21–24. novembar 1972. (str. 267–274). Ljubljana: ČGP Delo.
Ravančić, G. (2006). Crna smrt 1348.–1349. u Dubrovniku: srednjovjekovni grad i doživljaj epidemije (neobjavljena doktorska disertacija). Sveučilište u Zagrebu, Filozofski fakultet.
Ristanović, E., Gligić, A., Atanasievska, S., Protić-Đokić, V., Jovanović, D., & Radunović, M. (2017). Smallpox as actual biothreat: Lessons learned from its outbreak in ex-Yugoslavia in 1972. Annali dell’Istituto Superiore di Sanità, 52(4), 587–597. https://doi.org/10.4415/ann_16_04_21
Rokvić, V., Jeftić, Z., & Ajzenhamer, V. (2016). Public health in Serbia through the lens of security: A review article. Iranian Journal of Public Health, 45(11), 1457–1465.
Spreeuwenberg, P., Kroneman, M., & Paget, J. (2018). Reassessing the global mortality burden of the 1918 influenza pandemic. American Journal of Epidemiology, 187(12), 2561–2567. https://doi.org/10.1093/aje/kwy191
Šuvaković, U., Baljošević, S., & Obradović, Ž. (2014). Smallpox and globalization or the first achieved plannetary goal. Vojnosanitetski pregled, 71 (3), 301–306. https://doi.org/10.2298/VSP1403301S
Šuvaković, U., Petrović, J., & Pavlović, M. (2019). One hundred and thirty years from the birth of a medical lieutenant colonel and academician Kosta Todorović: Warrior, physician, scientist… humanist. Vojnosanitetski pregled, 76 (6), 653–660. https://doi.org/10.2298/VSP170723137S
Taylor, L. E., Swerdfeger, A. L., & Eslick, G. D. (2014). Vaccines are not associated with autism: An evidence-based meta-analysis of case-control and cohort studies. Vaccine, 32(29), 3623–3629. https://doi.org/10.1016/j.vaccine.2014.04.085
Teftedarija, M., Pokrajčić, B. i Konforti, H. (1973). Postvakcinalne komplikacije na području Sarajeva tokom epidemije velikih boginja u Jugoslaviji 1972. godine. U: Lj. Stojković, B. Birtašević, S. Borjanović, S. Litvinjenko, Ž. Perišić i V. Šuvaković (ur.), Epidemija velikih boginja u Beogradu 1972: Zbornik radova sa jugoslovenskog simpozijuma o velikim boginjama, Primošten, 21–24. novembar 1972. (str. 327–332). Ljubljana: ČGP Delo.
Transparency International Global Health. (2021, May 25). Lack of Transparency over Vaccine Trials, Secretive Contracts and ‘Science by Press Release’ Risk Success of Global COVID-19 Response. Retrieved August 14, 2024, from: https://www.transparency.org/en/press/covid-19-vaccines-lack-of-transparency-trials-secretive-contractsscience-by-press-release-risk-success-of-global-response
UNICEF. (n.d.) Understand SBC programmatic approaches: Social movements. SBC Guidance. Retrieved October 13, 2024, from: https://www.sbcguidance.org/understand/social-movements
Vasiljević, J. (1964). Osnivanje Centralnog higijenskog zavoda u Beogradu i njegov rad u periodu između dva rata (1919–1941). U: Zbornik radova Dvanaestog naučnog sastanka Naučnog društva za istoriju zdravstvene kulture Jugoslavije. Beograd: Naučno društvo za istoriju zdravstvene kulture Jugoslavije.
Vitiello, L., Ilari, S., Sansone, L., Belli, M., Cristina, M., Marcolongo, F., Tomino, C., Gatta, L., Mollace, V., Bonassi, S., Muscoli, C., & Russo, P. (2022). Preventive measures against pandemics from the beginning of civilization to nowadays—How everything has remained the same over the millennia. Journal of Clinical Medicine, 11(7), 1960. https://doi.org/10.3390/jcm11071960
Vučetić, R. (2022). Nevidljivi neprijatelj. Variola vera 1972. Beograd: JP Službeni glasnik.
Vučurović, M., Jovanovic, V., & Krcmar, O. (2023). Anti-vaccination movement as a supracultural phenomenon. European Journal of Public Health, 33, Issue Supplement 2, ckad160.1399. https://doi.org/10.1093/eurpub/ckad160.1399
Vuković, B., Miškov, D. i Mudrić, V. (1973). Postvakcinalne komplikacije nakon masovne vakcinacije protiv velikih boginja u Vojvodini 1972. godine. U: Lj. Stojković, B. Birtašević, S. Borjanović, S. Litvinjenko, Ž. Perišić i V. Šuvaković (ur.), Epidemija velikih boginja u Beogradu 1972: Zbornik radova sa jugoslovenskog simpozijuma o velikim boginjama, Primošten, 21–24. novembar 1972. (str. 321–326). Ljubljana: ČGP Delo.
Vuljevic, S. (2022, April 25). Vaccinating Yugoslavia: When communism beat smallpox. Eurozine. https://www.eurozine.com/vaccinating-yugoslavia-when-communism-beat-smallpox
Wolfe, R. M., & Sharp, L. K. (2002). Anti-vaccinationists past and present. BMJ, 325(7361), 430–432. https://doi.org/10.1136/bmj.325.7361.430
World Health Organization. (2011). Report of the Review Committee on the Functioning of the International Health Regulations (2005) in Relation to Pandemic (H1N1) 2009. Retrieved August 14, 2024, from: https://www.who.int/publications/i/item/report-of-the-review-committee-on-the-functioning-of-the-international-healthregulations-(2005)-in-relation-to-pandemic-(h1n1)-2009
World Health Organization. (2024). Global immunization efforts have saved at least 154 million lives over the past 50 years. WHO. Retrieved August 14, 2024, from: https://www.who.int/news/item/24-04-2024-global-immunization-efforts-have-saved-atleast-154-million-lives-over-the-past-50-years
Zdravković, A., Anđelković, N., Vujošević, N., Vuković Đurđević, D., Zonjić, S. et al. (1973). Iskustva sa karantinima tokom epidemije velikih boginja u Jugoslaviji 1972. godine. U: Lj. Stojković, B. Birtašević, S. Borjanović, S. Litvinjenko, Ž. Perišić i V.Šuvaković (ur.), Epidemija velikih boginja u Beogradu 1972: Zbornik radova sa jugoslovenskog simpozijuma o velikim boginjama, Primošten, 21–24. novembar 1972. (str. 280–291). Ljubljana: ČGP Delo.
Баљошевић, С. (2012). Велике богиње – variola maior, 40 година после епидемије. У: Б. Јовановић и У. Шуваковић (прир. и ур.), Косово и Метохија 1912–2012. Међународни тематски зборник (стр. 103–111). Косовска Митровица: Филозофски факултет Универзитета у Приштини са привременим седиштем у Косовској Митровици.
Јанковић, Т. (ур.). (1995). „Торлак”: 1930–1995. Београд: Завод за имунологију и вирусологију „Торлак”.
Катић, Р. В. (1965). О појавама и сузбијању болести код Срба од 1202. до 1813. године. Београд: Научно дело.
Ковачевић, С. (2022, 6. мај). Првих 100 година Пастеровог завода у Новом Саду. Политика Online. https://www.politika.rs/scc/clanak/506544/prvih-100-godinapasterovog-zavoda-u-novom-sadu
Кривошејев, В. А. (2022). Епидемије у Србији током ратова 1912–1918. Прилог квантификацији жртава. Баштина, 32 (58), 281–303. https://doi.org/10.5937/bastina32-36007
Милојевић, В. (1990). Пастеров завод у Нишу 1900–1985. Ниш: Завод за заштиту здравља – Научно друштво за историју здравствене културе Србије – Медицински факултет – Просвета.
Хиршвилд, Л. (1962). Историја једног живота. Београд: Српска књижевна задруга.
The details about the publication policy, including copyright and licensing, are available at:
