Kognitivni status i kvalitet života bolesnika nakon moždanog udara: dokazi iz Srbije
Sažetak
Uvod/Cilj. Moždani udar je veliki globalni zdravstveni problem i više od polovine bolesnika sa moždanim udarom pati od kognitivnih oštećenja. Cilj ove studije bio je da se proceni uticaj sekundarne rehabilitacije na kognitivni status i da se ispita njegova korelacija sa kvalitetom života kod bolesnika nakon moždanog udara. Metode. U studiji je učestvovalo ukupno 100 bolesnika (prosečne starosti 66,5 ± 7,3 godine), od kojih je 50 imalo dijagnozu ishemijskog moždanog udara (ischemic stroke – IS), a 50 je imalo dijagnozu intracerebralnog hemoragijskog moždanog udara (intracerebral hemorrhagic stroke – ICH). Test za procenu mentalnog stanja Mini-Mental State Examination (MMSE) korišćen je za procenu kognitivnog statusa, dok je Evropski upitnik za kvalitet života [European Quality of Life (EuroQol) 5-dimensional 3-level – EQ-5D-3L] korišćen za procenu kvaliteta života. Rezultati. Rezultati MMSE testa pokazali su značajne razlike nakon tri meseca (p = 0,037) i šest meseci (p = 0,009) trajanja sekundarne rehabilitacije u odnosu na prijem. Za EQ-5D-3L, uočene su značajne razlike u vreme prijema (p < 0,001), nakon mesec dana (p = 0,001) i šest meseci (p = 0,007). Uz to, Wilcoxon signed-rank test pokazao je statistički značajno poboljšanje i MMSE i EQ-5D-3L skorova bolesnika i sa IH i sa ICH, kada se uporede rezultati prijema s onima uzetim mesec dana (p < 0,001), tri meseca (p < 0,001) i šest meseci (p < 0,001) nakon sekundarne rehabilitacije. Zaključak. Rezultati ukazuju da postoji značajna korelacija između kognitivnog statusa i kvaliteta života merenog u sva četiri momenta. Dodatno, utvrđeno je da duže trajanje sekundarne rehabilitacije dovodi do poboljšanja kognitivnog statusa i višeg kvaliteta života bolesnika nakon moždanog udara.
Reference
Murphy SJ, Werring DJ. Stroke: causes and clinical features. Medicine (Abingdon) 2020; 48(9): 561–6.
Lindmark A, Eriksson M, Darehed D. Socioeconomic status and stroke severity: Understanding indirect effects via risk factors and stroke prevention using innovative statistical methods for mediation analysis. PLoS One 2022; 17(6): e0270533.
GBD 2019 Stroke Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 2021; 20(10): 795–820.
Ojaghihaghighi S, Vahdati SS, Mikaeilpour A, Ramouz A. Com-parison of neurological clinical manifestation in patients with hemorrhagic and ischemic stroke. World J Emerg Med 2017; 8(1): 34–8.
Bisevac E, Lazovic M, Nikolic D, Mahmutovic E, Dolicanin Z, Ju-risic-Skevin A. Postacute Rehabilitation Impact on Functional Recovery Outcome and Quality of Life in Stroke Survivors: Six Month Follow-Up. Medicina (Kaunas) 2022; 58(9): 1185.
Elendu C, Amaechi DC, Elendu TC, Ibhiedu JO, Egbunu EO, Ndam AR, et al. Stroke and cognitive impairment: under-standing the connection and managing symptoms. Ann Med Surg (Lond) 2023; 85(12): 6057–66.
Bour A, Rasquin S, Boreas A, Limburg M, Verhey F. How pre-dictive is the MMSE for cognitive performance after stroke? J Neurol 2010; 257(4): 630–7.
Cerniauskaite M, Quintas R, Koutsogeorgou E, Meucci P, Sattin D, Leonardi M, et al. Quality-of-life and disability in patients with stroke. Am J Phys Med Rehabil 2012; 91(13 Suppl 1): S39–47.
World Medical Association. World Medical Association Declara-tion of Helsinki: ethical principles for medical research involv-ing human subjects. JAMA 2013; 310(20): 2191–4.
McCurley JL, Funes CJ, Zale EL, Lin A, Jacobo M, Jacobs JM, et al. Preventing Chronic Emotional Distress in Stroke Survivors and Their Informal Caregivers. Neurocrit Care 2019; 30(3): 581–9.
Bugarski V, Semnic M, Golubović Š. Quick assessment of cogni-tive status and presence of depressive symptoms in acute phase of stroke. Psihijatrija danas 2009; 41(1–2): 29–41. (Serbian)
Stojković Ivković M. Mild cognitive impairment: The importance of early revealing and treatment options. Sestrinska reč 2017; 21(74): 24–6. (Serbian)
EuroQol Group Association. European Quality of Life-EuroQol EQ-5D [Internet]. Netherlands: EuroQol; 2025 [updated 2025 April 1; cited 2025 July 22]. Available from: https://euroqol.org/register/obtain-eq-5d/available-versions/
Janus-Laszuk B, Mirowska-Guzel D, Sarzynska-Dlugosz I, Czlonkowska A. Effect of medical complications on the after-stroke rehabilitation outcome. NeuroRehabilitation 2017; 40(2): 223–32.
Isaac V, Stewart R, Krishnamoorthy ES. Caregiver burden and quality of life of older persons with stroke: A community hos-pital study in South India. J Appl Gerontol 2011; 30(5): 643–54.
Mori N, Otaka Y, Honaga K, Matsuura D, Kondo K, Liu M, et al. Factors associated with cognitive improvement in subacute stroke survivors. J Rehabil Med 2021; 53(8): jrm00220.
Barbosa PM, Ferreira LN, Cruz VT, Silva A, Szrek H. Healthcare, Clinical Factors and Rehabilitation Predicting Quality of Life in First-time Stroke Patients: A 12-month Longitudinal Study. J Stroke Cerebrovasc Dis 2022; 31(4): 106300.
Paolucci S. Advances in antidepressants for treating post-stroke depression. Expert Opin Pharmacother 2017; 18(10): 1011–7.
Schneider S, Taba N, Saapar M, Vibo R, Kõrv J. Determinants of Long-Term Health-Related Quality of Life in Young Ischemic Stroke Patients. J Stroke Cerebrovasc Dis 2021; 30(2): 105499.
Capo-Lugo CE, Askew RL, Muldoon K, Maas M, Liotta E, Prab-hakaran S, et al. Longer Time Before Acute Rehabilitation Therapy Worsens Disability After Intracerebral Hemorrhage. Arch Phys Med Rehabil 2020; 101(5): 870–6.
Katzan IL, Schuster A, Newey C, Uchino K, Lapin B. Patient-reported outcomes across cerebrovascular event types: More similar than different. Neurology 2018; 91(23): e2182–91.
Gialanella B, Santoro R, Ferlucci C. Predicting outcome after stroke: the role of basic activities of daily living predicting outcome after stroke. Eur J Phys Rehabil Med 2013; 49(5): 629–37.
Ginex V, Vanacore N, Lacorte E, Sozzi M, Pisani L, Corbo M, et al. General cognition predicts post-stroke recovery defined through minimal clinically important difference (MCID): a cohort study in an Italian rehabilitation clinic. Eur J Phys Re-habil Med 2015; 51(5): 597–606.
Liu H, Lou VWQ. Functional recovery of older stroke pa-tients discharged from hospital to home: The effects of cogni-tive status and different levels of therapy intensity. J Clin Nurs 2019; 28(1–2): 47–55.
Seo KD, Kang MJ, Kim GS, Lee JH, Suh SH, Lee KY. National Trends in Clinical Outcomes of Endovascular Therapy for Is-chemic Stroke in South Korea between 2008 and 2016. J Stroke 2020; 22(3): 412–5.
Portegies ML, Bos MJ, Koudstaal PJ, Hofman A, Tiemeier HW, Ikram MA. Anxiety and the Risk of Stroke: The Rotterdam Study. Stroke 2016; 47(4): 1120–3.
Dimunová L, Soósová MS, Kardosová K, Červený M, Belovičová M. Quality of life in post-stroke patients. Kontakt 2021; 23(3): 157–61.
Su Y, Dong J, Sun J, Zhang Y, Ma S, Li M, et al. Cognitive function assessed by Mini-mental state examination and risk of all-cause mortality: a community-based prospective cohort study. BMC Geriatr 2021; 21(1): 524.
Bo W, Lei M, Tao S, Jie LT, Qian L, Lin FQ, et al. Effects of combined intervention of physical exercise and cognitive training on cognitive function in stroke survivors with vascu-lar cognitive impairment: a randomized controlled trial. Clin Rehabil 2019; 33(1): 54–63.
Gamito P, Oliveira J, Coelho C, Morais D, Lopes P, Pacheco J, et al. Cognitive training on stroke patients via virtual reality-based serious games. Disabil Rehabil 2017; 39(4): 385–8.
Shin M, Sohn MK, Lee J, Kim DY, Lee SG, Shin YI, et al. Effect of cognitive reserve on risk of cognitive impairment and re-covery after stroke: the KOSCO study. Stroke 2020; 51(1): 99–107.
Alawieh A, Zhao J, Feng W. Factors affecting post-stroke mo-tor recovery: Implications on neurotherapy after brain injury. Behav Brain Res 2018; 340: 94–101.
Dhandapani M, Joseph J, Sharma S, Dabla S, Varkey BP, Nara-simha VL, et al. The Quality of Life of Stroke Survivors in the Indian Setting: A Systematic Review and Meta-Analysis. Ann Indian Acad Neurol 2022; 25(3): 376–82.
