Inappropriate prescribing of antibiotics to the patients with acute bronchitis

Marijana S. Petrovic; Roland A. Antonic; Bojan I. Bagi; Irena M. Ilic; Aleksandar Goran Kocovic; Milos N. Milosavljevic; Nikola M. Nedovic; Ana V. Pejcic; Minela Z. Vapljanin; Admir M. Sabanovic; Slobodan M. Jankovic

doi:10.2298/VSP170731153P

Marijana S. Petrovic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Roland A. Antonic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Bojan I. Bagi University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Irena M. Ilic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Aleksandar Goran Kocovic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Milos N. Milosavljevic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Nikola M. Nedovic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Ana V. Pejcic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Minela Z. Vapljanin University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Admir M. Sabanovic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia
Slobodan M. Jankovic University of Kragujevac, Faculty of Medical Sciences, Kragujevac, Serbia

DOI: https://doi.org/10.2298/VSP170731153P

Ključne reči: bronhitis, antibiotici, faktori rizika, komorbiditet, lečenje, greške

Sažetak

Apstrakt

Uvod/Cilj. Neadekvatno propisivanje antibiotika bolesnicima sa akutnim bronhitisom česta je pojava u kliničkoj praksi, sa potencijalno ozbiljnim posledicama, iako većina vodiča za lečenje akutnog bronhitisa to ne preporučuje. Cilj naše studije bio je da se doprinese postojećim saznanjima o neodgovarajućem propisivanju antibiotika. Metode. Ova studija tipa slučaj/kontrola uključivala je odrasle bolesnike sa akutnim bronhitisom tokom prvog susreta sa lekarom opšte prakse. Propisivanje antibiotika je definisalo slučajeve, a bolesnici bez propisanog antibiotika služili su kao kontrola. Rezultati. Antibiotici (uglavnom makrolidi i beta-laktami) bili su propisani većini bolesnika sa dijagnozom akutnog bronhitisa (78,5%). Uočena je značajna povezanost između propisivanja antibiotika i starosti bolesnika, između propisivanja antibiotika i toga da li je lekar specijalista ili ne, kao i između propisivanja antibiotika i prosečnog broj bolesnika koje lekar pregleda tokom dana. Prilagođeni odnos šansi bio je [1,029 (1,007–1,052), 0,347 (0,147–0,818) i 0.957 (0.923–0.992), respektivno]. Zaključak. Prilikom prvog susreta bolesnika sa dijagnozom akutnog bronhitisa veću šansu da im antibiotik bude neadekvatno propisan imaju stariji bolesnici, posebno ako lekar nije specijalista i ako ima manji prosečan broj bolesnika u svojoj ordinaciji tokom dana.

Reference

REFERENCES

World Health Organization. Worldwide country situation analysis: Response to antimicrobial resistance. Geneva, Switzerland: World Health Organization; 2015.

Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf 2014; 5(6): 229–41.

World Health Organization. Interventions and Strategies to Im-prove the use of antimicrobials in developing countries: A re-view. Geneva, Switzerland: World Health Organization; 2001.

Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM, et al. Prevalence of Inappropriate Antibiotic Pre-scriptions Among US Ambulatory Care Visits, 2010-2011. JAMA 2016; 315(17): 1864–73.

Schroeck JL, Ruh CA, Sellick JA, Ott MC, Mattappallil A, Mergenha¬gen KA. Factors associated with antibiotic misuse in outpatient treatment for upper respiratory tract infections. Antimicrob Agents Chemother 2015; 59(7): 3848–52.

Harris AM, Hicks LA, Qaseem A. Appropriate Antibiotic Use for Acute Respiratory Tract Infection in Adults: Advice for High-Value Care From the American College of Physicians and the Centers for Disease Control and PreventionAppropri-ate Antibiotic Use. for Acute Respiratory Tract Infection in Adults. Ann Intern Med 2016; 164(6): 425–34.

Centre for Clinical Practice at NICE (UK). Respiratory Tract In-fec¬tions - Antibiotic Prescribing: Prescribing of Antibiotics for Self-Limiting Respiratory Tract Infections in Adults and Children in Primary Care. London: National Institute for Health and Clinical Excellence (UK); 2008

Smith SM, Fahey T, Smucny J, Becker LA. Antibiotics for acute bronchitis. Cochrane Database Syst Rev 2014; 3: CD000245.

McKay R, Mah A, Law MR, McGrail K, Patrick DM. Systematic Review of Factors Associated with Antibiotic Prescribing for Respiratory Tract Infections. Antimicrob Agents Chemother 2016; 60(7): 4106–18.

Magin PJ, Morgan S, Tapley A, Henderson KM, Holliday EG, Ball J, et al. Changes in early-career family physicians' antibiotic pre¬scribing for upper respiratory tract infection and acute bron¬chitis: A multicentre longitudinal study. Fam Pract 2016; 33(4): 360–7.

Sanchez GV, Roberts RM, Albert AP, Johnson DD, Hicks LA. Ef¬fects of knowledge, attitudes, and practices of primary care providers on antibiotic selection, United States. Emerging In-fect Dis 2014; 20(12): 2041–7.

Goossens H, Ferech M, Vanderstichele R, Elseviers M. Outpatient an¬tibiotic use in Europe and association with resistance: A cross-national database study. Lancet 2005; 365(9459): 579–87.

Dempsey PP, Businger AC, Whaley LE, Gagne JJ, Linder JA. Pri-mary care clinicians' perceptions about antibiotic prescribing for acute bronchitis: A qualitative study. BMC Fam Pract 2014; 15: 194.

Grijalva CG, Nuorti PJ, Griffin MR. Antibiotic prescription rates for acute respiratory tract infections in US ambulatory settings. JAMA 2009; 302(7): 758–66.

Barnett ML, Linder JA. Antibiotic prescribing for adults with acute bronchitis in the United States, 1996-2010. JAMA 2014; 311(19): 2020–2.

Ebell MH, Radke T. Antibiotic use for viral acute respiratory tract infections remains common. Am J Manag Care 2015; 21(10): e567–75.

Dooling KL, Kandeel A, Hicks LA, El-Shoubary W, Fawzi K, Kan-deel Y, et al. Understanding Antibiotic Use in Minya District, Egypt: Physician and Pharmacist Prescribing and the Factors Influencing Their Practices. Antibiotics (Basel) 2014; 3(2): 233–43.

Donnelly JP, Baddley JW, Wang HE. Antibiotic utilization for acute respiratory tract infections in U.S. emergency depart-ments. Antimicrob. Agents Chemother 2014; 58(3): 1451–7.

Malo S, Bjerrum L, Feja C, Lallana M, Moliner J, Rabanaque M. Compliance with recommendations on outpatient antibiotic prescribing for respiratory tract infections: The case of Spain. Basic Clin Pharmacol Toxicol 2015; 116(4): 337–42.

Dekker AR, Verheij TJ, Van der Velden AW. Inappropriate antibi¬otic prescription for respiratory tract indications: Most prominent in adult patients. Fam Pract 2015; 32(4): 401–7.

Kroening-Roche JC, Soroudi A, Castillo EM, Vilke GM. Antibiotic and bronchodilator prescribing for acute bronchitis in the emergency department. J Emerg Med 2012; 43(2): 221–7.

Murphy M, Bradley CP, Byrne S. Antibiotic prescribing in pri-mary care, adherence to guidelines and unnecessary prescrib-ing: An Irish perspective. BMC Fam Pract 2012; 13: 43.

Akkerman AE, van der Wouden JC, Kuyvenhoven MM, Dieleman JP, Verheij TJ. Antibiotic prescribing for respiratory tract infec¬tions in Dutch primary care in relation to patient age and clini¬cal entities. J Antimicrob Chemother 2004; 54(6): 1116–21.

Stone S, Gonzales R, Maselli J, Lowenstein SR. Antibiotic prescrib¬ing for patients with colds, upper respiratory tract infections, and bronchitis: A national study of hospital-based emergency departments. Ann Emerg Med 2000; 36(4): 320–7.

Ackerman SL, Gonzales R, Stahl MS, Metlay JP. One size does not fit all: Evaluating an intervention to reduce antibiotic pre-scribing for acute bronchitis. BMC Health Serv Res 2013; 13: 462.

Silverman M, Povitz M, Sontrop JM, Li L, Richard L, Cejic S, et al. Antibiotic Prescribing for Nonbacterial Acute Upper Respira¬tory Infections in Elderly Persons. Ann Intern Med 2017; 166(11): 765–74.

Linder JA, Singer DE, Stafford RS. Association between antibi-otic prescribing and visit duration in adults with upper respi-ratory tract infections. Clin Ther 2003; 25(9): 2419–30.