Povezanost vancrevnih manifestacija i kliničkih parametara sa indeksom histološke aktivnosti kod bolesnika sa inflamatornim bolestima creva

  • Miloš Štulić Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia
  • Djordje Ćulafić Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Serbia
  • Dragana Mijač Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Serbia
  • Goran Janković Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Serbia
  • Ivana Jovičić Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia;
  • Miodrag Krstić Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Serbia
  • Tomica Milosavljević Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Serbia
DOI: https://doi.org/10.2298/1423
Ključne reči: crohn disease||, ||kronova bolest, colitis, ulcerative||, ||kolitis, ulcerativni, severity of illness index||, ||bolest, indeks težine, signs and symptoms||, ||znaci i simptomi, histological techniques||, ||histološke tehnike,

Sažetak



Uvod/Cilj. Kronova bolest (Crohn's disease – CD) i ulcerozni kolitis (ulcerative colitis – UC) su hronične, idiopatske, zapaljenske bolesti digestivnog trakta. Cilj rada bio je da se utvrdi da li kod bolesnika sa CD i UC postoji uzajamni odnos između kliničkih pokazatelja stepena aktivnosti bolesti i prisustva vancrevnih manifestacija sa patohistološkim stepenom aktivnosti bolesti. Metode. Studija preseka obuhvatila je 134 bolesnika (67 sa CD i 67 sa UC) lečena u Klinici za gastroenterologiju Kliničkog centra Srbije u Beogradu. Nakon kliničke, laboratorijske, endoskopske, patohistološke i radiološke dijagnostike, bolesnici su na osnovu patohistološke aktivnosti bolesti podeljeni u dve grupe. U grupu I svrstano je 79 bolesnika čije su vrednosti petostepenog gradusa patohistološke aktivnosti bile manje od 5 (45 sa CD i 34 sa UC), dok je u grupi II bilo 55 bolesnika sa vrednostima većim od 5 (22 sa CD i 33 sa UC). Za kliničku procenu aktivnosti bolesti korišćen je indeks aktivnosti CD bolesti (CDAI) i Truelove i Wittsova skala za UC. Rezultati. Vancrevne manifestacije CD bile su prisutne kod 28,9% bolesnika grupe I i 63,6% bolesnika grupe II (p < 0,05). Upoređivanjem srednjih vrednosti CDAI uočena je statistički značajna razlika između dve grupe bolesnika (grupa I: 190,0 ± 83,0, grupa II: 263,4 ± 97,6; p < 0,05). Kod bolesnika sa UC nije utvrđena veza između prisustva vancrevnih manifestacija bolesti, Truelove i Wittsove skale i patohistološke aktivnosti bolesti (p > 0,05). Zaključak. Kod bolesnika sa CD prisustvo vancrevnih manifestacija, zajedno sa višim CDAI, ukazuje na veći stepen patohistološke aktivnosti bolesti. Nasuprot tome, kod bolesnika sa UC, Truelove i Wittsova skala i prisustvo vancrevnih manifestacija nisu bili pouzdani prediktori histološkog stepena aktivnosti bolesti.

Biografija autora

Miodrag Krstić, Clinic of Gastroenterology, Clinical Center of Serbia, Belgrade, Serbia; Faculty of Medicine, University of Belgrade, Serbia
Redovni profesor (Interna medicina), Medicinskog fakulteta Univerziteta u Beogradu. Zaposlen na Klinici za gastroenterologiju, KCS-a.

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Objavljeno
2017/01/20
Broj časopisa
Vol. 70 Br. 10 (2013)
Rubrika
Originalni članak