Brain metastases of choriocarcinoma – A report on two cases

Vera Milenković; Biljana Lazović; Ljiljana Mirković; Danica Grujičić; Radmila Sparić

doi:10.2298/1409

Vera Milenković Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic of Obstetrics and Gynecology, Clinical Center of Serbia, Belgrade, Serbia
Biljana Lazović Pulmology Department, Clinical Hospital Center Zemun, Zemun, Serbia
Ljiljana Mirković Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic of Obstetrics and Gynecology, Clinical Center of Serbia, Belgrade, Serbia
Danica Grujičić Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic of Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia
Radmila Sparić Faculty of Medicine, University of Belgrade, Belgrade, Serbia; Clinic of Neurosurgery, Clinical Center of Serbia, Belgrade, Serbia

DOI: https://doi.org/10.2298/1409

Ključne reči: choriocarcinoma||, ||horiokarcinom, neoplasm metastasis||, ||neoplazme, metastaze, brain neoplasms||, ||mozak, neoplazme, diagnosis||, ||dijagnoza, drug therapy||, ||lečenje lekovima, radiotherapy||, ||radioterapija, neurosurgical procedures||, ||neurohirurške procedure, treatment outcome||, ||lečenje, ishod,

Sažetak

Uvod. Gestacijske trofoblastne bolesti predstavljaju spektar tumora sa različitim biološkim ispoljavanjem i metastatskim potencijalom. Obuhvataju hidatiformnu molu, invazivnu molu, horiokarcinom i tumor placentnog ležišta. Horiokarcinom predstavlja agresivni tumor sa visokim malignim potencijalom. Prikaz bolesnika. U radu su prikazana dva bolesnika sa horiokarcinomom i metastatskim promenama u mozgu. Kod prvog bolesnika bolest se manifestovala neurološkom simptomatologijom kao prvim znakom horiokarcinoma, dok je kod druge bolesnice najpre bilo prisutno krvarenje iz materice, a u daljoj fazi javili su se neurološki poremećaji koji su ukazivali na prisustvo tumora u mozgu. Kod obe bolesnice primenjeno je kombinovano lečenje (hirurško odstranjenje tumora, hemio- i radioterapija) koje je dovelo do izlečenja. Zaključak. Uspešno lečenje metastaza na mozgu poreklom od horiokarcinoma postignuto je primenom hirurškog zbrinjavanja, hemioterapije i radioterapije. Kod mlađih bolesnika sa metastatskim promenama na mozgu, uvek bi trebalo razmišljati diferencijalno-dijagnostički i o ginekološkom malignitetu.

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Moždane metastaze horiokarcinoma

Sažetak

Reference