Promene u incidenci i anatomskoj distribuciji kolorektalnih adenoma i karcinoma u periodu od 20 godina – iskustvo jed

  • Tamara Alempijevic 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Vladimir Nikolic Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Simon Zec Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Aleksandar Veljkovic Faculty of Mathematics, University of Belgrade, Serbia
  • Aleksandra Sokic-Milutinovic 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Aleksandra Pavlovic-Markovic 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Vera Matovic Emergency Center, Clinical Center of Serbia, Serbia
  • Dusan Dj Popovic 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
  • Tomica Milosavljevic 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
DOI: https://doi.org/10.2298/VSP160409207A
Ključne reči: kolorektalne neoplazme;, adenom;, karcinom;, dijagnoza;, incidenca

Sažetak


Uvod/Cilj. Poslednjih godina mnoge studije su ukazale da je došlo do promene u distribuciji adenoma i karcinoma debelog creva, odnosno da se povećava zastupljenost proksimalnih lezija. Cilj ove studije je bio da se utvrdi postoji li razlika u zastupljenosti i distribuciji adenoma i karcinoma debelog creva u dva vremenska perioda sa razlikom od 20 godina. Metode. Sprovedena je retrospektivna opservaciona studija o kolorektalnim adenomima i karcinomima koji su dijagnostikovani kolonoskopski u tercijarnom zdravstvenom centru tokom 1990. i 2010. godine. Rezultati. Od ukupno 4,048 kolonoskopija izvedenih tokom dva analizirana perioda 1,148 je urađeno tokom 1990. a 2,900 je urađeno tokom 2010. godine. Studijom je obuhvaćeno 466 bolesnika sa adenomima i 121 bolesnik sa karcinomom debelog creva. Zastupljenost proksimalnih adenoma se promenila sa 16.5% na 32.7% (p < 0.001). Analizirajući kolonoskopije iz 2010. godine, uočen je porast incidencije adenoma u poređenju sa nalazom iz 1990. godine. Broj adenoma veličine 0–5 mm je porastao sa 32.8% na 56.9% (p < 0.001). Učestalost karcinoma kolona je promenjena sa 5.3% na 2.0% (p < 0.001). Zastupljenost karcinoma u proksimalnim partijama debelog creva je porasla sa 21.3% na 48.4% (p = 0.002). Uočena je veća incidenca karcinoma u proksimalnom kolonu i manja incidenca distalih karcinoma kolona, ali ne i razlika u incidenci kod rektalnog karcinoma. Zaključak. Pokazana je veća učestalost proksimalnih adenoma i kancera, dok je ukupna učestalost karcinoma kolona manja. Ovaj zaključak je značajan radi sprovođenja skrininga za kolorektalni karcinom.

Biografije autora

Tamara Alempijevic, 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Vladimir Nikolic, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Simon Zec, Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Aleksandar Veljkovic, Faculty of Mathematics, University of Belgrade, Serbia
Aleksandra Sokic-Milutinovic, 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Aleksandra Pavlovic-Markovic, 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Vera Matovic, Emergency Center, Clinical Center of Serbia, Serbia
Dusan Dj Popovic, 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia
Tomica Milosavljevic, 1. Clinic for Gastroenterology and Hepatology, Clinical Centre of Serbia, Belgrade, Serbia 2. Faculty of Medicine, University of Belgrade, Belgrade, Serbia

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Objavljeno
2020/11/17
Broj časopisa
Vol. 75 Br. 3 (2018): Vojnosanitetski pregled
Rubrika
Originalni članak