Minor neurological dysfunction in children aged 5 to 7

  • Maja Galić Preschool Teachers Training College Novi Sad, Novi Sad, Serbia
  • Aleksandra Mikov Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia
  • Slobodan Sekulić Clinical Center of Vojvodina, Clinic for Neurology, Novi Sad, Serbia
  • Aleksandar Kopitović Clinical Center of Vojvodina, Clinic for Neurology, Novi Sad, Serbia
  • Ivana Peričin Starčević Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia
Keywords: neurological manifestations;, risk;, child;, child, preschool;, age factors;, sex factors.

Abstract


Background/Aim. Assessment of minor neurological dysfunction (MND) provides information about a child's neurological condition which helps to identify the vulnerability of the child to the development of motor impairment, difficulties in learning or behavioral disorders. The aim of this study was to determine differences in the prevalence of MND in children from the general population with respect to age (5 and 6 years old) and sex. Methods. The examination was carried out in a preschool institution in the city of Novi Sad, Serbia. The total sample included 120 children divided into two groups according to age: 60 children aged 5 (group A) and 60 children aged 6 years (group B). The children were recruited at three randomly selected kindergartens and approximately equal sex representation, randomly selected as well. The testing was done by the Touwen's test, modified by Hadders-Algra. The results were classi­fied into three groups: the absence of MND, presence of simple MND (presence of one or two domains of dys­function) and the presence of complex MND (presence of at least three domains of dysfunction). Results. Sixty-seven children out of 120 (55.8%) had a normal neuro­logical condition, while 53 (44.2%) showed MND [49 (40.8%) simple, and 4 (3.4%) complex]. MND occurred more frequently in the youngest age group than in the older children (57% vs. 32%; p = 0.01). MND was also more frequent in boys than in girls, but this difference was not statistically significant. Conclusion. Our results show the importance of testing children at preschool age in order to detect potential neurological vulnerability and timely begin with the appropriate therapy.

References

REFERENCES

Touwen BC. Neurological development of the infant. In: Davis JA, Dobbing J, editors. Scientific Foundations of Paediatrics. 2nd ed. London: Heinemann Medical Books 1981. p. 830‒42.

Hadders-Algra M. Neurological examination of the child with minor neurological dysfunction. London: Mac Keith Press; 2010.

Lunsing RJ, Hadders-Algra M, Huisjes HJ, Touwen BC. Minor neurological dysfunction from birth to 12 years

Peters LH, Maathuis CG, Hadders-Algra M. Limited motor per-formance and minor neurological dysfunction at school age. Acta Paediatr 2011; 100(2): 271‒8. PubMed PMID: 20804459

Hadders-Algra M. The neuromotor examination of the pre-school child and its prognostic significance. Ment Retard Dev Disabil Res Rev 2005; 11(3): 180‒8.

Arnaud C, Daubisse-Marliac L, White-Koning M, Pierrat V, Lar-roque B, Grandjean H, et al. Prevalence and associated factors of minor neuromotor dysfunctions at age 5 years in prema-turely born children: The EPIPAGE Study. Arch Pediatr Adolesc Med 2007; 161(11): 1053‒61.

Kikkert HK, de Jong C, van den Heuvel ER, Hadders-Algra M. Minor neurological dysfunction and behaviour in 9-year-old children born at term: Evidence for sex dimorphism. Dev Med Child Neurol 2013; 55(11): 1023‒9.

Peters LH, Maathuis CG, Hadders-Algra M. Children with be-havioral problems and motor problems have a worse neurolog-ical condition than children with behavioral problems only. Early Hum Dev 2014; 90(12): 803‒7.

Stich H, Baune B, Caniato R, Mikolajczyk R, Kramer A. Individ-ual development of preschool children - prevalences and de-terminants of delays in Germany: A cross-sectional study in Southern Bavaria. BMC Pediatrics 2012; 12(1): 188.

Bennema AN, Schendelaar P, Seggers J, Haadsma ML, Heineman MJ, Hadders-Algra M. Predictive value of general movements' quality in low-risk infants for minor neurological dysfunction and behavioural problems at preschool age. Early Hum Dev 2016; 94: 19‒24.

Punt M, de Jong MD, de Groot ED, Hadders-Algra M. Minor neu-rological dysfunction in children with dyslexia. Dev Med Child Neurol 2010; 52(12): 1127‒32.

de Jong M, Punt M, de Groot E, Minderaa RB, Hadders-Algra M. Minor neurological dysfunction in children with autism spec-trum disorder. Dev Med Child Neurol 2011; 53(7): 641‒6.

Hsu J, Tsai M, Chu S, Fu R, Chiang M, Hwang F, et al. Early detection of minor neurodevelopmental dysfunctions at age 6 months in prematurely born neonates. Early Hum. Dev 2013; 89(2): 87‒93.

Schendelaar P. Offspring of subfertile couples: neurodevelop-mental outcomes at preschool age. [thesis]. Groningen: Uni-versity of Groningen; 2015.

Schendelaar P, van den Heuvel ER, Heineman MJ, La Bastide-van Gemert S, Middelburg KJ, Seggers J, et al. Increased time to pregnancy is associated with less optimal neurological condi-tion in 4-year-old singletons, in vitro fertilization itself is not. Hum Reprod 2014; 29(12): 2773‒86.

Kikkert HK, de Jong C, Hadders-Algra M. Minor neurological dysfunction and cognition in 9-year-olds born at term. Early Hum Dev 2013; 89(5): 263‒70.

Loke H, Harley V, Lee J. Biological factors underlying sex dif-ferences in neurological disorders. Int J Biochem Cell Biol 2015; 65: 139‒50.

Ruigrok AN, Salimi-Khorshidi G, Lai MC, Baron-Cohen S, Lom-bardo MV, Tait RJ, et al. A meta-analysis of sex differences in human brain structure. Neurosci Biobehav Rev 2014; 39: 34‒50.

Trabzuni D, Ramasamy A, Imran S, Walker R, Smith C, Weale ME, et al. Widespread sex differences in gene expression and splicing in the adult human brain. Nat Commun 2013; 4: 2771.

McCarthy MM, Arnold AP, Ball GF, Blaustein JD, de Vries GJ. Sex differences in the brain: The not so inconvenient truth. J Neurosci 2012; 32(7): 2241‒50.

Published
2020/12/08
Section
Short Report