Thoracoscore: Predicting risk of in-hospital mortality for patients undergoing pulmonary resection
Abstract
Background/Aim. Thoracic surgery is in need of a widely recognized and dependable risk model which could prospectively make objective conclusions and retrospectively allow comparison of outcomes. Thoracoscore is the first model with multiple variables developed for predicting in-hospital mortality following pulmonary resections. It is integrated in the British Thoracic Society and National Institute of Health and Clinical Excellence guidelines. However, additional evaluation of Thoracoscore is considerably advised in order to demonstrate its validity and potentially make it a dependable tool for thoracic surgeons across the world. Our study assesses the accuracy of Thoracoscore scoring system in estimating in-hospital mortality in patients undergoing pulmonary resections. Methods. Between September 2013 and October 2014 data were retrospectively collected on 196 patients operated on at the Thoracic Surgery Clinic, Institute of Pulmonary Diseases of Vojvodina. The procedures performed were: pneumonectomies, lobectomies and modified lobectomies (including bilobectomy and sleeve-lobectomy), Wedge resections and atypical resections. The Thoracoscore was calculated based on these nine variables: age, sex, American Society of Anaesthesiologists' (ASA) class, performance status classification, dyspnea score, priority of surgery, procedure class, diagnosis group and comorbidities score. Results. Study included one hundred and ninety-six patients, average age of 62 ± 9 years, and 61% were males. Predicted mean in-hospital mortality was 3.6 ± 3.2% 95% confidence interval (CI) 3.16–4.06, and mean actual in-hospital mortality was 6/196 (3.1%) (95% CI 1.78–4.42). Patients who were > 65 years old contributed to 3/6 (50%) of in-hospital mortality, and 4/6 (67%)were males. Four of 6 (67%) patients underwent pneumonectomy due to malignant pathology. Thoracoscore was divided into 4 risk groups: low (0–3), moderate (3.1–5), high (5.1–8) and very high (> 8). The correlation between observed and expected mortality was 0.99, by category of risk. Old age, male gender and malignancy showed to be strong indicators of in-hospital mortality. Conclusion. At our department Thoracoscore presented with good performance and as a practical tool for predicting in-hospital mortality among patients undergoing lung resections. However, any risk scoring system needs further validation before implementation and outcomes must be compared to those of other programs.
References
Falcoz PE, Conti M, Brouchet L, Chocron S, Puyraveau M, Mercier M, et al. The Thoracic Surgery Scoring System (Thoracoscore): Risk model for in-hospital death in 15, 183 patients requiring thoracic surgery. J Thorac Cardiovasc Surg 2007; 133(2): 325−32.
Chamogeorgakis T, Toumpoulis I, Tomos P, Ieromonachos C, Angouras D, Georgiannakis E, et al. External validation of the modified Thoracoscore in a new thoracic surgery program: Prediction of in-hospital mortality. Interact Cardiovasc Thorac Surg 2009; 9(3): 463−6.
Chamogeorgakis T, Connery CP, Bhora F, Nabong A, Toumpoulis IK. Thoracoscore predicts midterm mortality in patients undergoing thoracic surgery. J Thorac Cardiovasc Surg 2007; 134(4): 883−7.
Barua A, Handagala S, Socci L, Barua B, Malik M, Johnstone N, et al. Accuracy of two scoring systems for risk stratification in thoracic surgery. Interact Cardiovasc Thorac Surg 2012; 14(5): 556−9.
Pierce RJ, Copland JM, Sharpe K, Barter CE. Preoperative risk evaluation for lung cancer resection: Predicted postoperative product as a predictor of surgical mortality. Am J Respir Crit Care Med 1994; 150(4): 947−55.
Bernard A, Rivera C, Pages PB, Falcoz PE, Vicaut E, Dahan M. Risk model of in-hospital mortality after pulmonary resection for cancer: A national database of the French Society of Tho-racic and Cardiovascular Surgery (Epithor). J Thorac Cardio-vasc Surg 2011; 141(2): 449−58.
Berrisford R, Brunelli A, Rocco G, Treasure T, Utley M. Audit and guidelines committee of the European Society of Thoracic Surgeons.; European Association of Cardiothoracic Surge-ons.The European Thoracic Surgery Database project: model-ling the risk of in-hospital death following lung resection. Eur J Cardiothorac Surg 2005; 28(2): 306−11.
Harpole DH Jr, DeCamp MM Jr, Daley J, Hur K, Oprian CA, Henderson WG, et al. Prognostic models of thirty-day mortality and morbidity after major pulmonary resection. J Thorac Car-diovasc Surg 1999; 117(5): 969−79.
Ferguson MK, Durkin AE. A comparison of three scoring sys-tems for predicting complications after major lung resection. Eur J Cardiothorac Surg 2003; 23(1): 35−42.
Prause G, Offner A, Ratzenhofer-Komenda B, Vicenzi M, Smolle J, Smolle-Juttner F. Comparison of two preoperative indices to predict perioperative mortality in non-cardiac thoracic surgery. Eur J Cardiothorac Surg 1997; 11(4): 670−5.
Krowka MJ, Pairolero PC, Trastek VF, Payne WS, Bernatz PE. Cardiac dysrhythmia following pneumonectomy. Clinical cor-relates and prognostic significance. Chest 1987; 91(4): 490−5.
Bradley A, Marshall A, Abdelaziz M, Hussain K, Agostini P, Bishay E, et al. Thoracoscore fails to predict complications following elective lung resection. Eur Respir J 2012; 40(6): 1496−501.
Sharkey AJ, Ariyaratnam P, Belcher E, Kendall S, Naidu B, Parry W. Thoracoscore and European society objective score fail to predict mortality in a United Kingdom multicentre study. Interact Cardiovasc Thorac Surg 2013; 17(Suppl 2): S131.
