Diagnosis and treatment of COVID–19 in primary healthcare

  • Darinka Punoševac
Keywords: COVID-19, primary healthcare, treatment

Abstract


COVID-19 pandemic is caused by the SARS-Cov-2
virus and it was first isolated in Wuhan, China, in December
2019. In Primary Healthcare Center (PHC), Krusevac,
the outpatient clinic for respiratory infections was formed on
March 24th, 2020. Nearly 100.000 medical exams were performed
there, up til now.
The virus transmission is carried out by airborne droplets,
or rarely using contaminated hands. The entrance site of
the infection is nose, mouth, or eye mucose.
The infection develops in two stages. The first happens
in the upper respiratory tract (URT) and lasts 5-7 days, and
the second, when the virus descends to the lungs, and from
there causes systemic inflammation, primarily of the blood
vessels.
The diagnosis is based on the personal history, clinical
presentation, physical exam, specific viral tests, lab analysis,
and eventually, chest X-ray.
Therapy is mainly symptomatic, and since March 2021
we got antiviral favipiravir, and in January 2022 another antiviral,
molnupiravir, became available. Oral corticosteroids
showed promising results in patients with viral pneumonia.
Primary healthcare was a dam against the secondary
and tertiary healthcare this time, too. As our colleagues
worldwide, we were learning in stride, and the process is ongoing.
The more people get exposed to the virus, either naturally
or by vaccination, the sooner the pandemic will end but
not entirely and probably stay with us as a seasonal infection
with easier clinical presentation.

References

Mateus J, Dan JM, Moderbacher CR,

et al. Targets of T Cell Responses to

SARS-CoV-2 Coronavirus in Humans

with COVID-19 Disease and Unexposed

Individuals. Cell [Internet]. 2020 Jun 25

[cited 2022 Jan 24];181(7):1489-1501.e15.

Available from: https://pubmed.ncbi.nlm.

nih.gov/32473127

Foster KJ, Jauregui E, Tajudeen B,

Bishehsari F, Mahdavinia M. Smell loss

is a prognostic factor for lower severity

of coronavirus disease 2019. Ann Allergy,

Asthma Immunol [Internet]. 2020 Oct 1

[cited 2022 Jan 24];125(4):481. Available

from: https://www.ncbi.nlm.nih.gov/pmc/

articles/PMC7380219.

Overview of Testing for SARS-CoV-2,

the virus that causes COVID-19 |

CDC [Internet]. [cited 2022 Jan 24].

Available from: https://www.cdc.gov/

coronavirus/2019-ncov/hcp/testingoverview.

html

Tavakolpour S, Rakhshandehroo T, Wei

EX, Rashidian M. Lymphopenia during

the COVID-19 infection: What it shows

and what can be learned. Immunol Lett

[Internet]. 2020 Sep 1 [cited 2022 Jan

;225:31. Available from: https://

www.ncbi.nlm.nih.gov/pmc/articles/

PMC7305732/

PMC7305732/

ACR Recommendations for the use

of Chest Radiography and Computed

Tomography (CT) for Suspected

COVID-19 Infection | American College

of Radiology [Internet]. [cited 2022 Jan

. Available from https://www.acr.org/

Advocacy-and-Economics/ACR-Position-

Statements/Recommendations-for-Chest-

Radiography-and-CT-for-Suspected-

COVID19-Infection

Manabe T, Kambayashi D, Akatsu H,

Kudo K. Favipiravir for the treatment of

patients with COVID-19: a systematic

review and meta-analysis. BMC Infect

Dis [Internet]. 2021 Dec 1 [cited 2022 Jan

;21(1):1–13. Available from: https://

bmcinfectdis.biomedcentral.com/

articles/10.1186/s12879-021-06164-x

Molnupiravir dosing, indications,

interactions, adverse effects, and more

[Internet]. [cited 2022 Jan 24]. Available

from: https://reference.medscape.com/

drug/molnupiravir-4000252

COVID-19 & Antibiotic Resistance | CDC

[Internet]. [cited 2022 Jan 27]. Available

from:https://www.cdc.gov/drugresistance/

covid19.html

Corticosteroids | COVID-19 Treatment

Guidelines [Internet]. [cited 2022

Jan 24]. Available from:https://www.

covid19treatmentguidelines.nih.

gov/therapies/immunomodulators/

corticosteroids/

Published
2022/04/22
How to Cite
Punoševac, D. (2022). Diagnosis and treatment of COVID–19 in primary healthcare. General Practice, 28(1-2), 1-7. https://doi.org/10.5937/opmed28-34491
Section
Original article