Dinamika promene dužine telomera leukocita kod pacijenata sa blagim do umerenim COVID-19 tokom 3 nedelje praćenja: veza sa terapijom

Dužina telomera leukocita i COVID-19

  • Jelena Kotur-Stevuljević Faculty of Pharmacy Belgrade
  • Marina Roksandić Milenković Gradski zavod za tuberkulozu i plućne bolesti, Beograd
  • Jelena Vekić Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za medicinsku biohemiju
  • Nemanja Dimić Univerzitet u Beogradu, Medicinski fakultet, Univerzitetski kliničko-bolnički centar Dr Dragiša Mišović, Beograd
  • Dejan Dimić Gradski zavod za tuberkulozu i plućne bolesti, Beograd
  • Danica Ćujić Univerzitet u Beogradu, Institut za primenu niklearne energije INEP, Beograd
  • Azra Guzonjić Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za medicinsku biohemiju
  • Marija Gnjatović Univerzitet u Beogradu, Institut za primenu niklearne energije INEP, Beograd
  • Aleksandra Todorović Univerzitet u Beogradu, Institut za primenu niklearne energije INEP, Beograd
  • Nataša Bogavac-Stanojević Univerzitet u Beogradu, Farmaceutski fakultet, Katedra za medicinsku biohemiju
DOI: https://doi.org/10.5937/jomb0-63678
Ključne reči: COVID-19; oksidativni stres; dužina telomere; biomarker; vitamin D.

Sažetak


Kratak sadržaj

 

Uvod: Tokom trogodišnje pandemije COVID-19 otkriveno je da postoji čitav spektar težine bolesti i kliničkih manifestacija. Najintrigantniji deo ovog fenomena leži u interindividualnoj varijabilnosti toka COVID-19 među pacijentima, što se može pripisati starosti pacijenata, komorbiditetima i opštem zdravstvenom stanju. Fokus ove studije praćenja bio je da se proceni promena dužine telomera leukocita kod pacijenata sa blagim do umerenim COVID-19 i istovremeni uticaj inflamacije, oksidativnog stresa (OS), zahvaćenosti pluća i sprovedene terapije na tok bolesti. Metode: Rutinski biohemijski/hematološki parametri, markeri OS (prooksidanti i antioksidanti), nivo antitela na vitamin D, IgM i IgG i relativna dužina telomera leukocita (rLTL) mereni su u tri vremenske tačke (pri postavljanju dijagnoze, posle 14 i 21 dana od početak bolesti) u uzorcima krvi 31 pacijenta sa COVID-19, sa blagim (n=16) i umerenim (n=15) oblikom bolesti, lečenim ambulantno.

Rezultati: Iako su pacijenti imali smanjenu rLTL na početku (medijana: 0,592; 25. – 75. percentil: 0,518-0,724), ona se značajno povećavala tokom praćenja (medijana: 0,773; 25. – 75. percentil: 0,615-0,923; P<0,923). Stopa skraćivanja telomera bila je povezana sa obimom OS i zahvaćenosti pluća. Tokom praćenja, opterećenje OS je smanjeno, dok su antioksidantni odbrambeni mehanizmi oporavljeni. Upotreba antibiotika i suplementacije N-acetilcistein-propolisom bila je povezana sa produženjem telomera.

Zaključak: Rezultati ove studije otkrili su značajnu interakciju između OS, upale i smanjenja dužine telomera leukocita kod COVID-19. Naši podaci ukazuju da rRTL može biti biomarker koji omogućava precizniju odluku o terapiji i tačnu procenu statusa pacijenta.

 

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Objavljeno
2025/12/25
Broj časopisa
Ahead of print
Rubrika
Original paper

Sva prava zadržana (c) 2025 Jelena Kotur-Stevuljević, Marina Roksandić Milenković, Jelena Vekić, Nemanja Dimić, Dejan Dimić, Danica Ćujić, Azra Guzonjić, Marija Gnjatović, Aleksandra Todorović, Nataša Bogavac-Stanojević

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