The Улога инфламаторних биомаркера (IL-6, TNF-α, CRP), активације тромбоцита (CD62P, PAC-1, GPIIb/IIIa), генетске експресије (SERPINE1, F3) и предиктивног моделирања између депресије и ризика од тромбозе
Инфламаторни биомаркери (IL-6, TNF-α, CRP), активација тромбоцита (CD62P, PAC-1, GPIIb/IIIa), генетска експресија (SERPINE1, F3)
Ključne reči:
Депресија, тромбоза, упала, активација тромбоцита, ендотелна дисфункција, биомаркери, предвиђање ризика
Sažetak
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Reference
References
1. Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2019 (GBD 2019) Results. Seattle, United States: Institute for Health Metrics and Evaluation (IHME), 2020.
2. Jørgensen H, Horváth-Puhó E, Laugesen K, Brækkan SK, Hansen JB, Sørensen HT. Venous thromboembolism and risk of depression: a population-based cohort study. J Thromb Haemost. 2023;21(4):953-962.
3. Glise Sandblad K, Rosengren A, Sörbo J, Jern S, Hansson PO. Pulmonary embolism and deep vein thrombosis-comorbidities and temporary provoking factors in a register-based study of 1.48 million people. Res Pract Thromb Haemost. 2022;6(4):e12714.
4. Doulalas AD, Rallidis LS, Gialernios T, et al. Association of depressive symptoms with coagulation factors in young healthy individuals. Atherosclerosis. 2006;186(1):121-125.
5. von Känel R. The psychoneuroimmunological link between depression and cardiovascular disease. Handb Exp Pharmacol. 2022;270:307-348.
6. Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71(2):171-186.
7. Panagiotakos DB, Pitsavos C, Chrysohoou C, et al. Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. Eur Heart J. 2004;25(6):492-499.
8. Spalletta G, Bossù P, Ciaramella A, Bria P, Caltagirone C, Robinson RG. The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Mol Psychiatry. 2006;11(11):984-991.
9. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci. 2007;9(1):47-59.
10. Kop WJ, Gottdiener JS, Tangen CM, et al. Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol. 2002;89(4):419-424.
11. Kowal C, Peyre H, Amad A, et al. Psychotic, Mood, and Anxiety Disorders and Venous Thromboembolism: A Systematic Review and Meta-Analysis. Psychosom Med. 2020;82(9):838-849. (Cited for research gap: heterogeneity in findings)
12. Haapakoski R, Mathieu J, Ebmeier KP, Alenius H, Kivimäki M. Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun. 2015;49:206-215.
13. Valkanova V, Ebmeier KP, Allan CL. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord. 2013;150(3):736-744.
14. Amadio P, Zarà M, Sandrini L, Ieraci A, Barbieri SS. Depression and Cardiovascular Disease: The Viewpoint of Platelets. Int J Mol Sci. 2020;21(20):7565. (Cited for mechanism: endothelial dysfunction)
15. Izzi B, Tirozzi A, Cerletti C, et al. Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities. Int J Mol Sci. 2020;21(22):8817.
16. Morel A, Rywaniak J, Bijak M, Miller E, Niwald M, Saluk J. Flow cytometric analysis reveals the high levels of platelet activation parameters in circulation of multiple sclerosis patients. Mol Cell Biochem. 2017;430(1-2):69-80.
17. Li HY, Wang LH, Wang J, Wang YB, Wang HS. Causal association between major depressive disorder and venous thromboembolism: a bidirectional mendelian randomization study. Front Genet. 2024;15:1383333. (Cited for longitudinal/causal evidence)
18. Ward J, Le NQ, Suryakant S, et al. Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Adv. 2023;7(18):5341-5350. (Cited for longitudinal/causal evidence)
19. Kunutsor SK, Seidu S, Khunti K. Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence. Ann Med. 2018;50(6):529-537. (Cited for limitation: confounding by medication)
20. Hoirisch-Clapauch S, Nardi AE, Gris JC, Brenner B. Coagulation and mental disorders. Rambam Maimonides Med J. 2014;5(4):e0036. (Cited for research gap: need for integrated assessment)
21. Bossuyt X. Clinical performance characteristics of a laboratory test. A practical approach in the autoimmune laboratory. Autoimmun Rev. 2009;8(7):543-548. (Cited for methodological limitation of ELISA)
22. Harrison P, Lordkipanidzé M. Testing platelet function. Hematol Oncol Clin North Am. 2013;27(3):411-441. (Cited for methodological limitation of flow cytometry)
23. Kouba BR, de Araujo Borba L, Borges de Souza P, Gil-Mohapel J, Rodrigues ALS. Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets. Cells. 2024;13(5):391. (Cited for use/limitation of regression models)
24. Rosovsky RP, Mezue K, Gharios C, et al. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress-related neural mechanisms. Am J Hematol. 2024;99(10):1927-1938. (Cited for recent evidence and model)
25. Lee CW, Liao CH, Lin CL, Liang JA, Sung FC, Kao CH. Depression and risk of venous thromboembolism: a population-based retrospective cohort study. Psychosom Med. 2015;77(5):591-598.
26. von Känel R, Margani A, Stauber S, et al. Depressive symptoms as a novel risk factor for recurrent venous thromboembolism: a longitudinal observational study in patients referred for thrombophilia investigation. PLoS One. 2015;10(5):e0125858. (Cited for clinical implication: need for integration)
27. Klavina PA, Leon G, Curtis AM, Preston RJS. Dysregulated haemostasis in thrombo-inflammatory disease. Clin Sci (Lond). 2022;136(24):1809-1829.
1. Global Burden of Disease Collaborative Network. Global Burden of Disease Study 2019 (GBD 2019) Results. Seattle, United States: Institute for Health Metrics and Evaluation (IHME), 2020.
2. Jørgensen H, Horváth-Puhó E, Laugesen K, Brækkan SK, Hansen JB, Sørensen HT. Venous thromboembolism and risk of depression: a population-based cohort study. J Thromb Haemost. 2023;21(4):953-962.
3. Glise Sandblad K, Rosengren A, Sörbo J, Jern S, Hansson PO. Pulmonary embolism and deep vein thrombosis-comorbidities and temporary provoking factors in a register-based study of 1.48 million people. Res Pract Thromb Haemost. 2022;6(4):e12714.
4. Doulalas AD, Rallidis LS, Gialernios T, et al. Association of depressive symptoms with coagulation factors in young healthy individuals. Atherosclerosis. 2006;186(1):121-125.
5. von Känel R. The psychoneuroimmunological link between depression and cardiovascular disease. Handb Exp Pharmacol. 2022;270:307-348.
6. Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med. 2009;71(2):171-186.
7. Panagiotakos DB, Pitsavos C, Chrysohoou C, et al. Inflammation, coagulation, and depressive symptomatology in cardiovascular disease-free people; the ATTICA study. Eur Heart J. 2004;25(6):492-499.
8. Spalletta G, Bossù P, Ciaramella A, Bria P, Caltagirone C, Robinson RG. The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines. Mol Psychiatry. 2006;11(11):984-991.
9. Halperin D, Reber G. Influence of antidepressants on hemostasis. Dialogues Clin Neurosci. 2007;9(1):47-59.
10. Kop WJ, Gottdiener JS, Tangen CM, et al. Inflammation and coagulation factors in persons > 65 years of age with symptoms of depression but without evidence of myocardial ischemia. Am J Cardiol. 2002;89(4):419-424.
11. Kowal C, Peyre H, Amad A, et al. Psychotic, Mood, and Anxiety Disorders and Venous Thromboembolism: A Systematic Review and Meta-Analysis. Psychosom Med. 2020;82(9):838-849. (Cited for research gap: heterogeneity in findings)
12. Haapakoski R, Mathieu J, Ebmeier KP, Alenius H, Kivimäki M. Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun. 2015;49:206-215.
13. Valkanova V, Ebmeier KP, Allan CL. CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord. 2013;150(3):736-744.
14. Amadio P, Zarà M, Sandrini L, Ieraci A, Barbieri SS. Depression and Cardiovascular Disease: The Viewpoint of Platelets. Int J Mol Sci. 2020;21(20):7565. (Cited for mechanism: endothelial dysfunction)
15. Izzi B, Tirozzi A, Cerletti C, et al. Beyond Haemostasis and Thrombosis: Platelets in Depression and Its Co-Morbidities. Int J Mol Sci. 2020;21(22):8817.
16. Morel A, Rywaniak J, Bijak M, Miller E, Niwald M, Saluk J. Flow cytometric analysis reveals the high levels of platelet activation parameters in circulation of multiple sclerosis patients. Mol Cell Biochem. 2017;430(1-2):69-80.
17. Li HY, Wang LH, Wang J, Wang YB, Wang HS. Causal association between major depressive disorder and venous thromboembolism: a bidirectional mendelian randomization study. Front Genet. 2024;15:1383333. (Cited for longitudinal/causal evidence)
18. Ward J, Le NQ, Suryakant S, et al. Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Adv. 2023;7(18):5341-5350. (Cited for longitudinal/causal evidence)
19. Kunutsor SK, Seidu S, Khunti K. Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence. Ann Med. 2018;50(6):529-537. (Cited for limitation: confounding by medication)
20. Hoirisch-Clapauch S, Nardi AE, Gris JC, Brenner B. Coagulation and mental disorders. Rambam Maimonides Med J. 2014;5(4):e0036. (Cited for research gap: need for integrated assessment)
21. Bossuyt X. Clinical performance characteristics of a laboratory test. A practical approach in the autoimmune laboratory. Autoimmun Rev. 2009;8(7):543-548. (Cited for methodological limitation of ELISA)
22. Harrison P, Lordkipanidzé M. Testing platelet function. Hematol Oncol Clin North Am. 2013;27(3):411-441. (Cited for methodological limitation of flow cytometry)
23. Kouba BR, de Araujo Borba L, Borges de Souza P, Gil-Mohapel J, Rodrigues ALS. Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets. Cells. 2024;13(5):391. (Cited for use/limitation of regression models)
24. Rosovsky RP, Mezue K, Gharios C, et al. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress-related neural mechanisms. Am J Hematol. 2024;99(10):1927-1938. (Cited for recent evidence and model)
25. Lee CW, Liao CH, Lin CL, Liang JA, Sung FC, Kao CH. Depression and risk of venous thromboembolism: a population-based retrospective cohort study. Psychosom Med. 2015;77(5):591-598.
26. von Känel R, Margani A, Stauber S, et al. Depressive symptoms as a novel risk factor for recurrent venous thromboembolism: a longitudinal observational study in patients referred for thrombophilia investigation. PLoS One. 2015;10(5):e0125858. (Cited for clinical implication: need for integration)
27. Klavina PA, Leon G, Curtis AM, Preston RJS. Dysregulated haemostasis in thrombo-inflammatory disease. Clin Sci (Lond). 2022;136(24):1809-1829.
Objavljeno
2026/05/22
Broj časopisa
Rubrika
Original paper
Sva prava zadržana (c) 2026 Jinxia Zhang, Weijian Liu
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