Primary malignant teratoma of the mediastinum with poor outcome: A case report

Danica  Sazdanić-Velikić; Dušan  Škrbić; Djordje  Považan; Mirna  Djurić; Dejan  Vučković; Nevena  Sečen

doi:10.2298/VSP160331386S

Danica Sazdanić-Velikić University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for Thoracic Oncology, Sremska Kamenica, Serbia
Dušan Škrbić University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pneumology, Sremska Kamenica, Serbia
Djordje Považan University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pneumology, Sremska Kamenica, Serbia
Mirna Djurić University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pneumology, Sremska Kamenica, Serbia
Dejan Vučković University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska Kamenica, Serbia
Nevena Sečen University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for Thoracic Oncology, Sremska Kamenica, Serbia

DOI: https://doi.org/10.2298/VSP160331386S

Keywords: teratoma;, mediastinal neoplasms;, diagnostic techniques and procedures;, thoracic surgery;, neoplasm metastasis;, radiotherapy;, palliative care.

Abstract

Introduction. About 5%–10% of mediastinal tumors in adults are teratomas and about 85% of them are benign. Case report. We report a case of extragonadal malignant teratoma in a 39-year old man. The computed tomography (CT) scan of the chest revealed the soft-tissue density mass in the middle lobe of the lung. The posterolateral thoracotomy was performed and a mediastinal tumor of 25 cm was completely resected. Histopathological findings confirmed malignant teratoma. One month after the resection the positron emission tomography-computed tomography (PET/CT) scan of the whole body was performed and showed progression of the disease. Patient developed signs of the superior vena cava obstruction and received radiotherapy of the mediastinum and the metastatic lesion of the lumbal vertebra. After radiotherapy, the patient developed paraplegia and urinary incontinence and received the best supportive treatment. Conclusion. Primary extragonadal germ cell tumors have poor prognosis due to their relative chemoresistance and frequent findings of advanced disease after establishing the diagnosis.

Author Biographies

Dušan Škrbić, University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pneumology, Sremska Kamenica, Serbia

Clinic for general pneumology

Djordje Považan, University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pneumology, Sremska Kamenica, Serbia

Clinic for general pneumology, Head of pulmonary policlinic

Mirna Djurić, University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for General Pneumology, Sremska Kamenica, Serbia

Clinic for general pneumology, Head of department for acute pneumopathies

Dejan Vučković, University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Center for Pathology, Sremska Kamenica, Serbia

Center for pathology, Head of center for pathology

Nevena Sečen, University of Novi Sad, Faculty of Medicine, Institute for Pulmonary Diseases of Vojvodina, Clinic for Thoracic Oncology, Sremska Kamenica, Serbia

Clinic for thoracic oncology, Head of department for chemotherapy of lung cancer, CEOs Assistant for International Cooperation

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