Case Series of Burkholderia Pseudomallei Infections in Critically Ill Patients: Unveiling Key Challenges

Sažetak


Melioidosis remains a diagnostic challenge in tropical regions due to its broad clinical spectrum. This series presents seven diabetic individuals from an endemic area with diverse forms of the disease, including pulmonary, visceral, soft tissue and lymph node involvement. Laboratory confirmation was achieved through culture and nested polymerase chain reaction (PCR). Most patients improved with appropriate intravenous therapy followed by oral antibiotics; one experienced recurrence. The varied presentations often resemble other endemic infections, delaying diagnosis. Prompt clinical recognition and early use of molecular tools are vital for initiating targeted treatment and improving outcomes in vulnerable populations.

Biografije autora

Rishwanth Raja, Institut za visoko obrazovanje i istraživanje Šri Ramačandra

D.M. Postgraduate, Department of Critical Care Medicine

Baby K Sailaja, Institut za visoko obrazovanje i istraživanje Šri Ramačandra

Associate Professor, Department of Critical Care Medicine.

RV Hemalatha, Institut za visoko obrazovanje i istraživanje Šri Ramačandra

Assistant Professor, Department of Critical Care Medicine

Velmurugan Selvam, Institut za visoko obrazovanje i istraživanje Šri Ramačandra

Associate professor, Department of Critical Care Medicine

MK Renuka, Institut za visoko obrazovanje i istraživanje Šri Ramačandra

Professor & HOD, Department of Critical Care Medicine

Reference

Cheng AC, Currie BJ. Melioidosis: epidemiology, pathophysiology, and management. Clin Microbiol Rev. 2005 Apr;18(2):383-416. doi:10.1128/CMR.18.2.383-416.2005.

Currie BJ. Melioidosis: evolving concepts in epidemiology, pathogenesis, and treatment. Semin Respir Crit Care Med. 2015 Feb;36(1):111-25. doi:10.1055/s-0034-1398389.

Saravu K, Mukhopadhyay C, Vishwanath S, Valsalan R, Docherla M, Vandana KE, et al. Melioidosis in southern India: epidemiological and clinical profile. Southeast Asian J Trop Med Public Health. 2010 Mar;41(2):401-9. PMID:20578524.

Vidyalakshmi K, Shrikala B, Bharathi B, Suchitra U. Melioidosis: an under-diagnosed entity in western coastal India: a clinico-microbiological analysis. Indian J Med Microbiol. 2007 Jul;25(3):245-8. doi:10.4103/0255-0857.34767.

Dance DAB. Melioidosis as an emerging global problem. Acta Trop. 2000 Jul 3;

(2-3):115-9. doi:10.1016/S0001-706X(99)00061-9.

Wiersinga WJ, Virk HS, Torres AG, Currie BJ, Peacock SJ, Dance DAB, et al. Melioidosis. Nat Rev Dis Primers. 2018 Feb 1;4:17107. doi:10.1038/nrdp.2017.107.

Wuthiekanun V, Desakorn V, Wongsuvan G, Amornchai P, Cheng AC, Maharjan B, et al. Rapid immunofluorescence microscopy for diagnosis of melioidosis. Clin Diagn Lab Immunol. 2005 Apr;12(4):555-6. doi:10.1128/CDLI.12.4.555-556.2005.

Merritt A, Inglis TJ, Chidlow G, Harnett G. PCR-based identification of Burkholderia pseudomallei. Rev Inst Med Trop Sao Paulo. 2006 Sep-Oct;48(5):239-44. doi:10.1590/s0036-46652006000500001.

Objavljeno
2026/04/29
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