https://www.aseestant.ceon.rs/index.php/sanamed <p style="box-sizing: border-box; border: 0px; font-size: 16px; margin: 0px 0px 0.5em; outline: 0px; padding: 0px; vertical-align: baseline; color: #7a7a7a; font-family: Roboto, sans-serif;">SANAMED journal is international, peer-reviewed, multidisciplinary open-access medical journal, founded in 2006 and is published by the Association of medical doctors Sanamed, a nonprofit organization of physicians and scientists. The journal publishes: original articles, case reports, literature reviews, Systematic review, articles on history of medicine, articles for practitioners, book reviews, comments and letters to editor, and other medical information dedicated to the advancement of medical research, practice, and education, in the field of medicine and related fields.</p> <p style="box-sizing: border-box; border: 0px; font-size: 16px; margin: 0px 0px 0.5em; outline: 0px; padding: 0px; vertical-align: baseline; color: #7a7a7a; font-family: Roboto, sans-serif;">The journal is published both in electronic and print format, three times a year. Immediately after publication, all papers are available online for free, on the journal&rsquo;s website and other databases.</p> <p>The articles are printed in the English language with an abstract and title both in English and Serbian. Authors accept full responsibility for the accuracy of all content within the manuscript. Editor or Editorial Board of the Sanamed does not accept any responsibility for the statements in the articles.</p> <p>Submission of the manuscript implies that its publication has been approved by the responsible authorities at the institution where the work has been carried out. The publisher will not be held legally responsible should be any claims for compensation. Details of all funding sources for the work should be given.</p> Association of medical doctors "Sanamed" Novi Pazar en-US Sanamed 1452-662X <p class="gmail_msg"><span class="lG">Journal </span><span class="lG">Sanamed </span>is published under an Open Access license. All its content is available free of charge. Users can read, download, copy, distribute, print, search the full text of articles, as well as establish HTML links to them, without having to seek the consent of the author or publisher.</p> <p class="gmail_msg">The right to use content without consent does not release the users from the obligation to give the credit to the <span class="lG">journal </span>and its content in a manner described under CC BY.</p> https://www.aseestant.ceon.rs/index.php/sanamed/article/view/62550 <p class="Default" style="margin-top: 0in; text-align: justify; text-justify: inter-ideograph; line-height: normal; mso-hyphenate: none; tab-stops: .5in 1.0in 1.5in 2.0in 2.5in 3.0in 3.5in 4.0in 4.5in 5.0in 5.5in 6.0in;"><strong><span style="font-family: 'Times Roman','serif';">Objective:</span></strong><span style="font-family: 'Times Roman','serif';"> To evaluate potential drug&ndash;drug interactions (pDDIs) involving analgesics in hospitalized urological patients and identify risk factors influencing their number.</span></p> <p class="Default" style="margin-top: 0in; text-align: justify; text-justify: inter-ideograph; line-height: normal; mso-hyphenate: none; tab-stops: .5in 1.0in 1.5in 2.0in 2.5in 3.0in 3.5in 4.0in 4.5in 5.0in 5.5in 6.0in;"><strong><span style="font-family: 'Times Roman','serif';">Methods:</span></strong><span style="font-family: 'Times Roman','serif';"> This study involved a post hoc analysis based on data obtained from a retrospective observational cohort clinical study conducted at the Clinic of Urology, University Clinical Centre Kragujevac, Serbia. Of the original 220 patients, 191 who received analgesics were included. Daily pharmacotherapy data, along with demographic and clinical characteristics, were collected, while pDDIs were identified and classified using the Lexicomp Interaction Checker. Descriptive statistics were used to summarize the data. Multiple linear regression with backward elimination was used to identify independent predictors of the number of pDDIs.</span></p> <p class="Default" style="text-align: justify; text-justify: inter-ideograph; line-height: normal; mso-hyphenate: none; tab-stops: .5in 1.0in 1.5in 2.0in 2.5in 3.0in 3.5in 4.0in 4.5in 5.0in 5.5in 6.0in; margin: 0in 0in 12.0pt 0in;"><strong><span style="font-family: 'Times Roman','serif';">Results:</span></strong><span style="font-family: 'Times Roman','serif';"> Analgesic-related pDDIs were detected in 175 patients (91.6%). Non-steroidal anti-inflammatory drugs (NSAIDs) were prescribed to 173 patients (90.6%), opioids to 53 (27.7%), and paracetamol to 54 (28.3%). The mean number of pDDIs per patient was 5.5 &plusmn; 5.5 (range 0&ndash;30). Category X interactions most frequently included NSAID combinations (diclofenac + ketorolac, ketorolac + metamizole), while category D interactions frequently involved enoxaparin + ketorolac and opioid&ndash;benzodiazepine pairs. Category C interactions were dominated by NSAID + potassium chloride and tramadol + ondansetron or atropine combinations. Multiple regression analysis identified diabetes, a higher number of prescribed drugs, and the use of NSAIDs or opioids as positive predictors of the number of pDDIs, whereas a cancer diagnosis was associated with a lower number.</span></p> <p class="Default" style="text-align: justify; text-justify: inter-ideograph; line-height: normal; mso-hyphenate: none; tab-stops: .5in 1.0in 1.5in 2.0in 2.5in 3.0in 3.5in 4.0in 4.5in 5.0in 5.5in 6.0in; margin: 0in 0in 12.0pt 0in;"><strong><span style="font-family: 'Times Roman','serif';">Conclusion:</span></strong><span style="font-family: 'Times Roman','serif';"> Analgesic-related pDDIs affect the majority of hospitalized urological patients. Avoiding high-risk combinations, close monitoring, and multidisciplinary medication review in patients with risk factors may help reduce preventable harm.</span></p> Ivan Milovanović Ana Pejčić Zoran Kovačević Katarina Janićijević Copyright (c) 2026 Sanamed https://creativecommons.org/licenses/by/4.0 2026-01-26 2026-01-26 10.5937/sanamed0-62550