Kliničke karakteristike i dijagnostika COVID-19 kod pacijenata u COVID-ambulantama u opštoj medicini

Miloranka Petrov Kiurski; slavoljub Živanović

doi:10.5937/opmed28-35902

Miloranka Petrov Kiurski https://orcid.org/0000-0002-5789-2367
slavoljub Živanović gradski zavod za hitnu medicinsku pomoć beograd https://orcid.org/0000-0002-2553-7774

DOI: https://doi.org/10.5937/opmed28-35902

Ključne reči: Simptomi COVID-19, PCR test, ishodi, opšta medicina

Sažetak

Cilj rada. Ispitati koje su kliničke manifestacije, rezultate
PCR testiranja i ishod posete kod pacijenata u COVID-
ambulantama u opštoj medicini.
Metod. Istraživanje je sprovedeno upitnikom februara
2021. god. među pacijentima u četiri COVID-ambulante
u Beogradu i jednoj u Subotici. Dobijeni su podaci o polu,
starosti, postojećim simptomima i komorbiditetima, PCR-testiranju
i ishodu posete. Podaci su obrađeni softverskim statističkim
paketom SPSS 17. Statistička značajnost je definisana
za nivo p<0,05,
Rezultati. Obuhvaćeno je 676 ispitanika oba pola,
prosečne starosti 49 godina. Lekaru su se javljali 1-3 dana
nakon pojave simptoma. Najčešći simptomi su bili povišena
temperatura i kašalj, zatim umor i bolovi u mišićima. Hipertenzija
i gojaznost su najčešći komorbiditeti, većinom kod
starijih od 65 godina (p=0,000). Testirano je 92% ispitanika
PCR testom, i od njih 676, 60,95% je bilo PCR pozitivno,
najčešće stariji od 50 godina (p=0,010). Zbog težine kliničke
slike, 17,3% ispitanika upućeno je na bolničko lečenje, najčešće
> od 51 do 65 godina, ali razlika nije statistički značajna
(p=0,183).
Zaključak. Najčešći simptomi COVID-19 su povišena
temperatura i kašalj, a ispitanici su se lekaru javili, u proseku,
nakon 1 do 3 dana od pojave simptoma. Od komorbiditeta,
najčešća su bili hipertenzija i gojaznost, češće kod ispitanika
starijih od 65 godina. Kod više od polovine ispitanika PCR
test je bio pozitivan, najčešće kod starijih od 50 godina.

Reference

Khan AH, Tirth V, Fawzy M, Mahmoud AED, Khan NA, Ahmed S, et al. COVID-19 transmission, vulnerability, persistence and nanotherapy: a review. Environ Chem Lett [Internet]. 2021 Aug 1 [cited 2021 Aug 6];19(4):2773–87. Available from: https://pubmed.ncbi.nlm.nih.gov/33846683/>

Anand U, Cabreros C, Mal J, Ballesteros F, Sillanpää M, Tripathi V, et al. Novel coronavirus disease 2019 (COVID-19) pandemic: From transmission to control with an interdisciplinary vision. Environ Res [Internet]. 2021 Jun 1 [cited 2021 Jul 30];197. Available from: https://pubmed.ncbi.nlm.nih.gov/33831411/>

Rahman S, Montero MTV, Rowe K, Kirton R, Kunik F. Epidemiology, pathogenesis, clinical presentations, diagnosis and treatment of COVID-19: a review of current evidence. Expert Rev Clin Pharmacol [Internet]. 2021 [cited 2021 Jul 30];14(5):601–21. Available from: https://pubmed.ncbi.nlm.nih.gov/33705239/>

Yang X, Chen X, Ding C, Bai Z, Zhu J, Sun G, et al. Epidemiological Investigation and Prevention Control Analysis of the Longitudinal Distribution of COVID-19 in Henan Province, China. mSphere [Internet]. 2020 Oct 28 [cited 2021 Jul 30];5(5). Available from: https://pubmed.ncbi.nlm.nih.gov/33028688/>

Cheng JL, Huang C, Zhang GJ, Liu DW, Li P, Lu CY, et al. [Epidemiological characteristics of novel coronavirus pneumonia in Henan]. Zhonghua Jie He He Hu Xi Za Zhi [Internet]. 2020 Mar 2 [cited 2021 Jul 30];43(0):E027. Available from: http://www.ncbi.nlm.nih.gov/pubmed/32118390>

Mallah SI, Ghorab OK, Al-Salmi S, Abdellatif OS, Tharmaratnam T, Iskandar MA, et al. COVID-19: breaking down a global health crisis. Ann Clin Microbiol Antimicrob [Internet]. 2021 Dec 1 [cited 2021 Jul 30];20(1). Available from: https://pubmed.ncbi.nlm.nih.gov/34006330/>

Struyf T, Deeks JJ, Dinnes J, Takwoingi Y, Davenport C, Leeflang MMG, et al. Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19. Cochrane Database Syst Rev [Internet]. 2021 Feb 23 [cited 2021 Jul 30];2021(2). Available from: https://pubmed.ncbi.nlm.nih.gov/33620086/>

Rothan HA BS. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. J Autoimmun [Internet]. 2020 May 1 [cited 2021 Aug 6];109. Available from: https://pubmed.ncbi.nlm.nih.gov/32113704/>

Afshar-Oromieh A, Prosch H, Schaefer-Prokop C, Bohn KP, Alberts I, Mingels C, et al. A comprehensive review of imaging findings in COVID-19 - status in early 2021 [Internet]. Vol. 48, European Journal of Nuclear Medicine and Molecular Imaging. Eur J Nucl Med Mol Imaging; 2021 [cited 2021 Jul 30]. p. 2500–24. Available from: https://pubmed.ncbi.nlm.nih.gov/33932183/>

Regmi K, Lwin CM. Factors associated with the implementation of non-pharmaceutical interventions for reducing coronavirus disease 2019 (Covid-19): A systematic review. Int J Environ Res Public Health [Internet]. 2021 Apr 2 [cited 2021 Jul 30];18(8). Available from: https://pubmed.ncbi.nlm.nih.gov/33920613/>

Luo X, Liu Y, Ren M, Zhang X, Janne E, Lv M, et al. Consistency of recommendations and methodological quality of guidelines for the diagnosis and treatment of COVID-19. J Evid Based Med [Internet]. 2021 Feb 1 [cited 2021 Jul 30];14(1):40–55. Available from: https://pubmed.ncbi.nlm.nih.gov/33565225/>

Mardian Y, Kosasih H, Karyana M, Neal A, Lau CY. Review of Current COVID-19 Diagnostics and Opportunities for Further Development. Front Med [Internet]. 2021 May 7 [cited 2021 Jul 30];8. Available from: https://pubmed.ncbi.nlm.nih.gov/34026773/>

Teymouri M, Mollazadeh S, Mortazavi H, Naderi Ghale-noie Z, Keyvani V, Aghababaei F, et al. Recent advances and challenges of RT-PCR tests for the diagnosis of COVID-19. Pathol Res Pract [Internet]. 2021 May 1 [cited 2021 Jul 30];221. Available from: https://pubmed.ncbi.nlm.nih.gov/33930607/>

Ahmad A, Ishtiaq SM, Khan JA, Aslam R, Ali S, Arshad MI. COVID-19 and comorbidities of hepatic diseases in a global perspective [Internet]. Vol. 27, World Journal of Gastroenterology. World J Gastroenterol; 2021 [cited 2021 Jul 30]. p. 1296–310. Available from: https://pubmed.ncbi.nlm.nih.gov/33833483/>

Kermani-Alghoraishi M. A Review of Coronary Artery Thrombosis: A New Challenging Finding in COVID-19 Patients and ST-elevation Myocardial Infarction. Curr Probl Cardiol [Internet]. 2021 Mar 1 [cited 2021 Jul 30];46(3). Available from: https://pubmed.ncbi.nlm.nih.gov/33218787/>

Madjid M, Safavi-Naeini P, Solomon SD, Vardeny O. Potential Effects of Coronaviruses on the Cardiovascular System: A Review. JAMA Cardiol [Internet]. 2020 Jul 1 [cited 2021 Jul 30];5(7):831–40. Available from: https://pubmed.ncbi.nlm.nih.gov/32219363/>

Li G, Saguner AM, An J, Ning Y, Day JD, Ding L, et al. Cardiovascular disease during the covid-19 pandemic: Think ahead, protect hearts, reduce mortality. Cardiol J [Internet]. 2020 [cited 2021 Jul 30];27(5):616–24. Available from: https://pubmed.ncbi.nlm.nih.gov/32789839/>

Sen M, Honavar SG, Sharma N, Sachdev MS. COVID-19 and eye: A review of ophthalmic manifestations of COVID-19. Indian J Ophthalmol [Internet]. 2021 Mar 1 [cited 2021 Jul 30];69(3):488–509. Available from: https://pubmed.ncbi.nlm.nih.gov/33595463/>

Nie Y, Li J, Huang X, Guo W, Zhang X, Ma Y, et al. Epidemiological and clinical characteristics of 671 COVID-19 patients in Henan Province, China. Int J Epidemiol [Internet]. 2020 Aug 1 [cited 2021 Jul 30];49(4):1085–95. Available from: https://pubmed.ncbi.nlm.nih.gov/32588051/>

Song Q, Sun X, Dai Z, Gao Y, Gong X, Zhou B, et al. Point-of-care testing detection methods for COVID-19. Lab Chip [Internet]. 2021 May 7 [cited 2021 Jul 30];21(9):1634–60. Available from: https://pubmed.ncbi.nlm.nih.gov/33705507/>

Krishnan A, Hamilton JP, Alqahtani SA, A.Woreta T. A narrative review of coronavirus disease 2019 (COVID-19): clinical, epidemiological characteristics, and systemic manifestations [Internet]. Vol. 16, Internal and Emergency Medicine. Intern Emerg Med; 2021 [cited 2021 Jul 30]. p. 815–30. Available from: https://pubmed.ncbi.nlm.nih.gov/33453010/>

Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med [Internet]. 2020 Apr 30 [cited 2021 Aug 8];382(18):1708–20. Available from: https://pubmed.ncbi.nlm.nih.gov/32109013/>

Gane SBC, Kelly C, Hopkins C. Isolated Sudden onset anosmia in COVID-19 infection. A novel syndrome? Rhinology [Internet]. 2020 [cited 2021 Jul 30];58(3):299–301. Available from: https://pubmed.ncbi.nlm.nih.gov/32240279/>

Di Salvo E, Di Gioacchino M, Tonacci A, Casciaro M, Gangemi S. Alarmins, COVID-19 and comorbidities. Ann Med. 2021;53(1):777–85.

Al-Hosani F, Al-Mazrouei S, Al-Memari S, Al-Yafei Z, Paulo MS, Koornneef E. A Review of COVID-19 Mass Testing in the United Arab Emirates. Front Public Heal [Internet]. 2021 May 12 [cited 2021 Jul 30];9. Available from: https://pubmed.ncbi.nlm.nih.gov/34055725/>

Alkhathami M, Advani S, Abalkhail A, Alkhathami F, Alshehri M, Albeashy E, et al. Prevalence and mortality of lung comorbidities among patients with COVID-19: A systematic review and meta-analysis. Lung India [Internet]. 2021 [cited 2021 Jul 30];38(7):31. Available from: https://pubmed.ncbi.nlm.nih.gov/33686977/>