Predictive Value of Biochemical Markers CRP, WBC, and Total Cholesterol for Postoperative Dry Eye Syndrome Following Phacoemulsification Cataract Surgery

Validating CRP, WBC, TC for Dry Eye Post-Phacoemulsification

  • Yenan Wang Department of ophthalmology, Xuanwu Hospital, Capital Medical University
  • Xizhe Wang Department of ophthalmology, Xuanwu Hospital, Capital Medical University
  • Zhen Li Department of ophthalmology, Xuanwu Hospital, Capital Medical University
  • Huiqing Yang Department of ophthalmology, Xuanwu Hospital, Capital Medical University
  • Xuxiang Zhang Department of ophthalmology, Xuanwu Hospital, Capital Medical University
DOI: https://doi.org/10.5937/jomb0-59665
Keywords: C-reactive protein, White blood cell count, Total cholesterol, Biochemical markers, Cataract surgery, Dry eye syndrome, Predictive diagnostics

Abstract


Background: Dry eye syndrome is a common complication following phacoemulsification cataract surgery, potentially influenced by systemic biochemical factors. This study aimed to evaluate the predictive efficiency of three routinely measured biochemical markers—C-reactive protein (CRP), white blood cell count (WBC), and total cholesterol (TC)—in identifying patients at risk for postoperative dry eye syndrome.
Methods: A total of 87 patients undergoing phacoemulsification between January 2024 and February 2025 were enrolled and categorized into dry eye (n=49) and non-dry eye (n=38) groups. Blood samples were collected preoperatively to assess CRP, WBC, and TC levels using standard laboratory protocols. Baseline characteristics were compared, and multivariate logistic regression was conducted to identify independent risk factors. Receiver operating characteristic (ROC) curves were generated to determine the predictive performance of each marker and their combination.

Results: Patients in the dry eye group exhibited significantly elevated CRP, WBC, and TC levels compared to the non-dry eye group (P<0.001 for all). Multivariate analysis identified CRP (OR=12.679), WBC (OR=3.216), and TC (OR=1.258) as independent predictors. The area under the ROC curve (AUC) values for CRP, WBC, and TC were 0.791, 0.770, and 0.757, respectively, while the combined model yielded an AUC of 0.936, indicating superior diagnostic performance (P<0.01).

Conclusion: CRP, WBC, and TC levels are clinically accessible biochemical parameters that hold significant predictive value for dry eye syndrome following cataract surgery. Combined detection enhances prognostic accuracy and may guide early intervention strategies to reduce postoperative complications.

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Published
2025/08/08
Issue
Ahead of print
Section
Original paper

Copyright (c) 2025 Yenan Wang, Xizhe Wang, Zhen Li, Huiqing Yang, Xuxiang Zhang

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