Uticaj teških metala na zdravlje ljudi i pojavu autizma
Sažetak
Toksikologija hrane objašnjava načine unosa toksina iz hrane, raspodelu u organizmu, kao i metabolizam i izlučivanje. Toksini se mogu prirodno naći u namirnicama, dospeti iz spoljne sredine, ali je značajan i ljudski faktor. Dijagnostički kriterijumi i skrining, porast svesti šire stručne i društvene javnosti, kao i brojne defektološke metode rada su inicirali veću osetljivost za poremećaje iz spektra autizma (PSA). Ovaj pregled prisustva teških metala u hrani, govori o njihovim toksikološkim osobinama i štetnosti po zdravlje ljudi. Kako je prevalenca broja dece iz spektra autizma sve veća, a etiologija nepoznata, može se skrenuti pažnja i na uticaj teških metala kao spoljnjih faktora (koji se unose hranom) na pojavu ovog razvojnog poremećaja.
Reference
Đulančić N. Toksikologija hrane. Sarajevo: Poljoprivredno-prehrambeni fakultet, Univerzitet u Sarajevu; 2016.
Jokanović M. Toksikologija. Beograd: Mikro knjiga; 2010.
Klapec T. Toksikologija hrane. Osijek: Prehrambeno-tehnološki fakultet, Sveučilište Josipa Jurja Strossmayera; 2023.
Sofilić T, Makić H. Toksikologija. Zagreb: Metalurški fakultet, Sveučilište u Zagrebu; 2019.
Jokić N, Tešanović B. Bezbednost ishrane i kvalitet života. Vojno delo. 2017;69(6):180–195.
Marković M. Bezbednost hrane – interna skripta. Beograd: Škola rezervnih oficira Vojske Srbije; 2020.
Biščan V, Cindrić I. Teški metali u hrani. Zaštita na radu i zaštita zdravlja. Karlovac: Sveučilište u Karlovcu; 2010. p. 153–160.
Vasić-Rački Đ, Galić K, Delaš F. Kemijske i fizikalne opasnosti u hrani. Osijek: Hrvatska agencija za hranu; 2010. p. 21.
Danilović B, Potić V, Stamenković S, Savić N. Pregled prisustva nekih kontaminanata hrane na teritoriji Republike Srbije. Adv Technol. 2017;6(2):84–95.
Agency for Toxic Substances and Disease Registry. Toxicological profile for lead. Atlanta (GA): U.S. Department of Health and Human Services; 2007 [cited 2024]. Available from: http://www.atsdr.cdc.gov/toxprofiles/tp13.html
Agency for Toxic Substances and Disease Registry. Toxicological profile for cadmium. Atlanta (GA): U.S. Department of Health and Human Services; 2008 [cited 2024]. Available from: http://www.atsdr.cdc.gov/toxprofiles/tp5.html
Agency for Toxic Substances and Disease Registry. Toxicological profile for arsenic. Atlanta (GA): U.S. Department of Health and Human Services; 2008 [cited 2024 Apr 19]. Available from: http://www.atsdr.cdc.gov/toxprofiles/tp2.html.
Choong TSY, Chuah TG, Robiah Y, Koay FLG, Azni I. Arsenic toxicity, health hazards and removal techniques from water: an overview. Desalination. 2007;217:139–66.
Tasić Ž, Bogdanović G, Antonijević M. Primena prirodnih zeolita u tretmanu otpadnih voda. J Min Metall A Min. 2019;55(1):67–79.
Maksimović N, Kisić Tepavčević D. Autizam i MMR vakcina. In: Stremljenja i novine u medicini; 46. simpozijum. Beograd: Medicinski fakultet Univerziteta u Beogradu, Institut za epidemiologiju; 2017.
Tomić K, Jurišić V, Muratović M, Jevtović I. Značaj serotonina u etiologiji autizma. PONS Med J. 2010;:64–69.
Kogan MD, Vladutiu CJ, Schieve LA, Ghandour RM, Blumberg SJ, Zablotsky B, et al. Prevalence of parent-reported autism spectrum disorder among US children. Pediatrics. 2018;142(6):e20174161.
Rühl D, Bölte S, Feinein-Metthews S, Poustka F. ADOS: Diagnostische Beobachtungsskala für autistische Störungen. 1st ed. Bern: Hans Huber; 2004.
National Institute for Health and Care Excellence. Autism: recognition, referral and diagnosis of children and young people on the autism spectrum (NICE guideline CG128). London: NICE; 2011 [cited 2025]. Available from: https://www.nice.org.uk/guidance/cg128
Marić N, Predojević J, Malčić D. Genetika autizma. Trendovi u molekularnoj biologiji. 2024;(4):44–55.
McNamara IM, Borella AW, Bialowas LA, WhitakerAzmitia PM. Further studies in the developmental hyperserotonemia model (DHS) of autism: social, behavioral and peptide changes. Brain Res 2008;1189: 203‒14.
Stoner R, Chow Boyle MP, Sunkin SM, Mouton PR, Roy S. Patches of disorganization in the neocortex of children with autism. N Engl J Med. 2012;370(13):1209–1219.
Babić M. Uzroci autizma. Nauka u Srbiji [Internet]. 2021 [cited 2025 Feb 9]. Available from: portal Kleiner FS, Mamiya CJ, Tansey RG.
Harris JC. Autism spectrum disorder. In: Zigmond MJ, Rowland LP, Coyle JT, editors. Neurobiology of brain disorders: biological basis of neurological and psychiatric disorders. Cambridge: Academic Press; 2015. p. 78–96.
Aschner M, Costa LG. Environmental factors in neurodevelopmental and neurodegenerative disorders. Cambridge: Academic Press; 2015.
Landrigan PJ, Lambertini L, Birnbaum LS. A research strategy to discover the environmental causes of autism and neurodevelopmental disabilities. Environ Health Perspect. 2012;120:258–260.
Bojanić N, Milenković J, Stojanović D, Milojković M, Đinđić N. Patofiziološki mehanizmi aluminijumske toksičnosti. Acta Medica Medianae. 2020;59(1):100–109.
Sealey LA, Hughes BW, Sriskanda AN, Guest JR, Gibson AD, Johnson-Williams L, Pace DG, Bagasra O. Environmental factors in the development of autism spectrum disorders, Environ Int. 2016;88:288–298.
Chauhan V, Chauhan A. Contribution of oxidative stress to the pathophysiology of autism spectrum disorders: impact of genetic and environmental factors. In: Dietrich-Muszalska A, Chauhan V, Gringon S, editors. Studies on psychiatric disorders. New York: Humana Press; 2015.
Ljutić P. Upotreba i primjena zeolita. Zagreb: Zdravstveno veleučilište; 2022. Available from: urn:nbn:hr:139:316854
