Sveobuhvatan pregled testa direktne reaktivnosti peptida u ispitivanju preosetljivosti kože: Primenjivost, ograničenja i razmatranja

  • Elma Omeragić Univerzitet u Sarajevu – Farmaceutski fakultet
  • Belma Imamović Univerzitet u Sarajevu – Farmaceutski fakultet
  • Mirza Dedić Univerzitet u Sarajevu – Farmaceutski fakultet
  • Indira Mujezin Univerzitet u Sarajevu – Fakultet zdravstvenih studija; Javna Ustanova Dom zdravlja Kantona Sarajevo
  • Ervina Bečić Univerzitet u Sarajevu – Farmaceutski fakultet
DOI: https://doi.org/10.5937/arhfarm74-49552
Ključne reči: DPRA, hemijska metoda, senzibilizacija kože

Sažetak


Senzibilizacija kože je ključna tačka u proceni bezbednosti hemikalija, pri čemu se test direktnog reaktiviteta peptida (DPRA) pojavljuje kao dragocena hemijska metoda za procenu potencijala senzibilizacije supstance. Ovaj pregled istražuje principe, primenljivost i ograničenja DPRA u kontekstu okvira nepovoljnog ishoda puta (AOP) za senzibilizaciju kože. Istražujemo ulogu DPRA u adresiranju molekularno inicirajućeg događaja senzibilizacije kože, njegovu integraciju u integrisane pristupe testiranju i proceni (IATA) i njegovu efikasnost u predviđanju senzibilizatora. Pregled takođe ističe izazove u testiranju određenih kategorija hemikalija i važnost razmatranja rezultata DPRA zajedno sa drugim komplementarnim metodama. Pružanjem sveobuhvatnog pregleda DPRA, ovaj pregled ima za cilj da informiše istraživače, regulatorne organe i kliničare o njegovoj korisnosti i ograničenjima u kontekstu testiranja senzibilizacije kože.

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Objavljeno
2024/04/28
Broj časopisa
Vol. 74 Br. Notebook 2 (2024): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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