Mogućnost zamene konvencionalnih organskih rastvarača zelenim dubokim eutektičkim rastvaračima u analitici lekova

  • Đorđe Vasilić Agencija za lekove i medicinska sredstva Srbije
  • Marija Rašević Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za analitiku lekova
  • Mira Zećević Univerzitet u Beogradu - Farmaceutski fakultet, Katedra za analitiku lekova
  • Marija Čarapić Agencija za lekove i medicinska sredstva Srbije
  • Andjelija Malenović Univerzitet u Beogradu – Farmaceutski fakultet, Katedra za analitiku lekova
DOI: https://doi.org/10.5937/arhfarm74-49545
Ključne reči: eutektički rastvarači, zeleni rastvarači, tečna hromatografija, analitika lekova

Sažetak


Poslednjih godina, eutektički rastvarači privlače sve veću pažnju u različitim naučnim disciplinama. Njihova jedinstvena svojstva, kao što su niska toksičnost, biorazgradivost, niska cena i mogućnost primene u različitim oblastima, učinila su ih atraktivnom alternativom konvencionalnim organskim rastvaračima. U farmaceutskoj analizi, gde su sve veći zahtevi za ekološki prihvatljivim metodama, postavlja se pitanje da li eutektički rastvarači, kao „zeleni rastvarači“, mogu da zamene organske rastvarače. Ovaj rad istražuje potencijalnu primenu eutektičkih rastvarača u analizi lekova i ističe prednosti i izazove koje oni donose. Prikazani su primeri upotrebe eutektičkih rastvarača u hromatografiji i u ekstrakciji lekova iz različitih uzoraka. Pored toga, razmatrana je stabilnost i toksičnost eutektičkih rastvarača koji se koriste u analitičkim metodama. Na osnovu dostupnih podataka, može se zaključiti da eutektički rastvarači imaju značajan potencijal u pogledu upotrebe u analitičkim metodama u farmaceutskoj analizi i pružanja ekološki održive i efikasne alternative konvencionalnim organskim rastvaračima. Međutim, potrebna su dalja istraživanja kako bi se bolje razumela njihova svojstva i optimizovala njihova primena u ispitivanju lekova.

Reference

Liu J, Li X, Ho Row K. Development of deep eutectic solvents for sustainable chemistry. J Molec Liq. 2022;362:119654.

El Achkar T, Greige-Gerges H, Fourmentin, S. Basics and properties of deep eutectic solvents: a review. Environ Chem Lett. 2021;19(4):3397–3408.

Abbott AP, Boothby D, Capper G, Davies DL, Rasheed RK. Deep Eutectic Solvents Formed between Choline Chloride and Carboxylic Acids: Versatile Alternatives to Ionic Liquids. J Am Chem Soc. 2004;126(29):9142–9147.

Smith EL, Abbott AP, Ryder KS. Deep Eutectic Solvents (DESs) and Their Applications. Chem Rev. 2014;114(21):11060-11082.

Płotka-Wasylka J, de la Guardia M, Andruch V, Vilková M. Deep eutectic solvents vs ionic liquids: Similarities and differences. Microchem J. 2020;159:105539.

Sharma A, Sharma RC, Thakur R, Singh L. An overview of deep eutectic solvents: Alternative for organic electrolytes, aqueous systems & ionic liquids for electrochemical energy storage. J Energy Chem. 2023;82:592-626.

Ijardar SP, Singh V, Gardas RL. Revisiting the Physicochemical Properties and Applications of Deep Eutectic Solvents. Molecules. 2022;27(4):1368.

Florindo C, Oliveira FS, Rebelo LPN, Fernandes AM, Marrucho IM. Insights into the Synthesis and Properties of Deep Eutectic Solvents Based on Cholinium Chloride and Carboxylic Acids. ACS Sustain Chem Eng. 2014;2(10):2416–2425.

Pandey A, Pandey S. Solvatochromic Probe Behavior within Choline Chloride-Based Deep Eutectic Solvents: Effect of Temperature and Water. J Phys Chem B. 2014;118(50):14652–14661.

Abbasi NM, Farooq MQ, Anderson JL. Investigating the Variation in Solvation Interactions of Choline Chloride-Based Deep Eutectic Solvents Formed Using Different Hydrogen Bond Donors. ACS Sustain Chem Eng. 2021;9(35):11970–11980.

Wang H, Liu S, Zhao Y, Wang J, Yu Z. Insights into the Hydrogen Bond Interactions in Deep Eutectic Solvents Composed of Choline Chloride and Polyols. ACS Sustain Chem Eng. 2019;7(8):7760–7767.

Shah PA, Chavda V, Hirpara D, Sharma VS, Shrivastav PS, Kumar S. Exploring the potential of deep eutectic solvents in pharmaceuticals: Challenges and opportunities. J Mol Liq. 2023;390:123171.

Tomé LIN, Baião V, da Silva W, Brett CMA. Deep eutectic solvents for the production and application of new materials. Appl Mater Today. 2018;10:30-50.

Jablonský M, Škulcová A, Šima J. Use of Deep Eutectic Solvents in Polymer Chemistry-A Review. Molecules. 2019;24(21):3978.

Li L, Wu Z, Liang J, Yu L. Application of deep eutectic solvents in lignocellulosic biomass processing. J For Eng. 2020;4:20-28.

Crema APS, Schaeffer N, Bastos H, Silva L, Abranches DO, Passos H, et al. New family of Type V eutectic solvents based on 1,10-phenanthroline and their application in metal extraction. Hydrometallurgy. 2022;215(6):105971.

Piao H, Jiang Y, Qin Z, Ma P, Sun Y, Wang X, et al. Application of an in-situ formulated magnetic deep eutectic solvent for the determination of triazine herbicides in rice. Talanta. 2021;222:121527.

Hu C, Feng J, Cao Y, Chen L, Li Y. Deep eutectic solvents in sample preparation and determination methods of pesticides: Recent advances and future prospects. Talanta. 2024;266:125092.

Zhang J, Zhang Z, Yao L, Qian M, Li Z, Han Y, et al. pH-responsive switchable deep eutectic solvents to mediate pretreatment method for trace analysis of triazole fungicides in peel wastes. Food Chem. 2023;411:135486.

Chen Z, Jacoby WA, Wan C. Ternary deep eutectic solvents for effective biomass deconstruction at high solids and low enzyme loadings. Bioresour Technol. 2019;279:281-286.

Meenu M, Bansal V, Rana S, Sharma N, Kumar V, Arora V, Garg M. Deep eutectic solvents (DESs) and natural deep eutectic solvents (NADESs): Designer solvents for green extraction of anthocyanin. Sustain Chem Pharm. 2023;34:101168.

Omar KA, Sadeghi R. Physicochemical properties of deep eutectic solvents: A review. J Mol Liq. 2022;360:119524.

Zhang Q, De Oliveira Vigier K, Royer S, Jérôme F. Deep eutectic solvents: syntheses. properties and applications. Chem Soc Rev. 2012;41(21):7108.

Skulcova A, Russ A, Jablonsky M, Sima J. The pH behavior of seventeen deep eutectic solvents. Bio Res. 2018;13(3):5042-5051.

Hayyan M, Ali Hashim M, Hayyan AH, Al-Saadi MA, Al Nashef IM, Mirghani MES, Kola SO. Are deep eutectic solvents benign or toxic? Chemosphere. 2013;90:2193-2195.

Wen Q, Chen J, Tang Y, Wang J, Yang Z. Assessing the toxicity and biodegradability of deep eutectic solvents. Chemosphere. 2015;132:63-69.

Sharma A, Lee BS. Toxicity test profile for deep eutectic solvents: A detailed review and future prospects. Chemosphere. 2024;350:141097.

Azzouz A, Hayyan M. Are deep eutectic solvents biodegradable? PSEP. 2024;176:1021-1025.

Chen J, Yun L, Wang X, Liu W. Application of Deep Eutectic Solvents in Food Analysis: A Review. Molecules. 2019;24(4):4594.

Perna MF, Vitale P, Capriati V. Deep eutectic solvents and their applications as green solvents. Curr Opin Green Sustain Chem. 2020;21:27-33.

Taheri E, Yousefinejad S, Dehghani F. Deep eutectic solvents in biological monitoring of occupational exposures. TrAC. 2023;168:117299.

Gao F, Liu L, Tang W, Ho Row K, Zhu T. Optimization of the chromatographic behaviors of quercetin using choline chloride-based deep eutectic solvents as HPLC mobile-phase additives. Sep Sci Technol. 2018;53(2):397-403.

Ramezani MA, Ahmadi R, Absalan G. Designing a sustainable mobile phase composition for melamine monitoring in milk samples based on micellar liquid chromatography and natural deep eutectic solvent. J Chromatogr A. 2020;1610:460563.

Pérez-López LA, Cavazos-Rocha N, Delgado-Montemayor C, Waksman-Minsky N, Hernández-Salazar M, Portillo-Castillo OJ. A simple HPLC-DAD method for analysis of phenolic acids: Addition effect of a hydrophilic deep eutectic solvent to the mobile phase. Acta Chromatogr. 2023;35(2):204-216.

Płotka-Wasylka J, Rutkowska M, de la Guardia M. Are deep eutectic solvents useful in chromatography? A short review. J Chromatogr A. 2021;1639:461918.

Sutton AT, Fraige K, Mazzi Leme G, da Silva Bolzani V, Hilder EF, Cavalheiro AJ, et al. Natural deep eutectic solvents as the major mobile phase components in high-performance liquid chromatography – searching for alternatives to organic solvents. Anal Bioanal Chem. 2018;410:3705–3713.

Yang B, Cai T, Li Z, Guan M, Qiu H. Surface radical chain-transfer reaction in deep eutectic solvents for preparation of silica-grafted stationary phases in hydrophilic interaction chromatography. Talanta. 2017;175:256-263.

Momotko M, Łuczak J, Przyjazny A, Boczkaj G. First deep eutectic solvent-based (DES) stationary phase for gas chromatography and future perspectives for DES application in separation techniques. J Chromatogr A. 2012;1635:461701.

Makoś-Chełstowska P, Gębicki J. Sorbents modified by deep eutectic solvents in microextraction techniques, TrAC. 2024;172:117577.

Tan T, Zhang M, Wan Y, Qiu H. Utilization of deep eutectic solvents as novel mobile phase additives for improving the separation of bioactive quaternary alkaloids. Talanta. 2016;149:85-90.

Tan T, Qiao X, Wan Y, Qiu H. Deep eutectic solvent: a new kind of mobile phase modifier for hydrophilic interaction liquid chromatography. Chin J Chromatogr (Se Pu). 2015;33(9):934-937.

Gao F, Liu L, Tang W, Row KH, Zhu T. Optimization of the chromatographic behaviors of quercetin using choline chloride-based deep eutectic solvents as HPLC mobile-phase additives. Sep Sci Technol. 2017;53(2):397–403.

Li G, Zhu T, Lei Y. Choline chloride-based deep eutectic solvents as additives for optimizing chromatographic behavior of caffeic acid. Korean J Chem Eng. 2015;32(10):2103–2108.

Ninayan R, Levshakova AS, Khairullina EM, Vezo OS, Tumkin I, Ostendorf A, et al. Water-induced changes in choline chloride-carboxylic acid deep eutectic solvents properties. Colloids Surf A: Physicochem Eng Asp. 2023;679:132543.

Sazali AL, Al Masoud N, Amran SK, Alomar TS, Pa'ee KF, El-Bahy ZM, et al. Physicochemical and thermal characteristics of choline chloride-based deep eutectic solvents, Chemosphere. 2023;338:139485.

Raj D. Eutectic Thin-Layer Chromatography as a New Possibility for Quantification of Plant Extracts-A Case Study. Molecules. 2022;27(9):2960.

Liu Y, Friesen JB, McAlpine JB, Lankin DC. Chen SN, Pauli GF. Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives. J Nat Prod. 2018;81(3):679-690.

Ramezani MA, Absalan G. Employment of a natural deep eutectic solvent as a sustainable mobile phase additive for improving the isolation of four crucial cardiovascular drugs by micellar liquid chromatography. J Pharm Biomed Anal. 2020;186:113259.

Salido-Fortuna S, Casado N, Castro-Puyana M, Luisa Marina M. Use of choline chloride-D-sorbitol deep eutectic solvent as additive in cyclodextrin-electrokinetic chromatography for the enantiomeric separation of lacosamide. Microchem J. 2021;160:105669.

Jiang Z-M, Liu W-J, Li Y, Liu J, Wang H-Y, Li P, Liu E-H. Eco-friendly deep eutectic solvents contribute to improving the separation of isoquinoline alkaloids in supercritical fluid chromatography. ACS Sustainable Chem Eng. 2020;36:13777–13783.

Objavljeno
2024/04/28
Broj časopisa
Vol. 74 Br. Notebook 2 (2024): Arhiv za farmaciju
Rubrika
Pregledni (Revijalni) rad
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