Acute myocardial infarction in patients under 45 years of age - what has changed in 10 years?

Danijela Djordjević Radojković; Miodrag Damjanović; Svetlana  Apostolović; Jelena Milošević; Dragana Stanojević; Goran Koraćević; Ružica Janković Tomašević; Tomislav Kostić; Sonja Dakić; Jelena Cvetković; Jovana Šarić

doi:10.5937/afmnai41-49993

Assist. dr Danijela Djordjević Radojković Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia; Faculty of Medicine, University of Niš, Niš 18000, Serbia
dr Miodrag Damjanović Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia
Prof. dr Svetlana Apostolović Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia; Faculty of Medicine, University of Niš, Niš 18000, Serbia
dr Jelena Milošević Klinika za kardiologiju Nis
dr Dragana Stanojević Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia
Prof. dr Goran Koraćević Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia; Faculty of Medicine, University of Niš, Niš 18000, Serbia
dr Ružica Janković Tomašević Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia
Prof. dr Tomislav Kostić Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia; Faculty of Medicine, University of Niš, Niš 18000, Serbia
Assist. dr Sonja Dakić Cardiology Clinic, University Clinical Center Niš, Niš 18000, Serbia; Faculty of Medicine, University of Niš, Niš 18000, Serbia
Jelena Cvetković Faculty of Medicine, University of Niš, Niš 18000, Serbia
Jovana Šarić Faculty of Medicine, University of Niš, Niš 18000, Serbia

DOI: https://doi.org/10.5937/afmnai41-49993

Keywords: myocardial infarction, young patients, risk factors

Abstract

Introduction: The aim of the research was to compare patients under the age of 45 years with acute myocardial infarction (AMI) at a ten-year interval, in order to detect changes in frequency and risk factoris of AMI.

Material and methods: The retrospective study included patients under the age of 45 years, hospitalized at the Cardiology Clinic, University Clinical Center Niš, with a diagnosis of AMI during 2023 and 2013. The frequency of heart attacks, risk factors for coronary disease, the way of presentation and prevalence of coronary disease in both groups were compared.

Results: During the 10-year period, the total number of patients annually hospitalized with AMI increased (985 vs 1691). The proportion of younger patients increased significantly, from 18 (1.7%) in 2013 to 57 (3.4%) in 2023, p=0.008. The youngest patient with AMI in 2013 was 31 years old, and in 2023 - 25 years old. The groups differed significantly in average age (43.3 years in 2013 vs 33.2 years in 2023, p=0.02). Significantly more patients had dyslipidemia (89.8% vs 47.1%) and positive family history (87.8% vs 47.1%) in the 2023 group. The majority of patients in both groups presented with STEMI and the majority had single-vessel disease. During 2023, the number of younger patients with three-vessel disease increased (5.3% vs 0%).

Conclusion: The proportion of patients aged up to 45 years among patients with AMI in our community has increased over the ten-year period, the average age and the minimum age of this patient group have decreased.

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